INT349583

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.57
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
neuron 2
Aap (Mus musculus)
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 498 100.00 Very High Very High Very High
cINOD 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 57 98.16 Very High Very High Very High
Apoptosis 48 98.08 Very High Very High Very High
Death 138 89.84 High High
Injury 3 80.56 Quite High
Acute Renal Failure 3 79.32 Quite High
Drug Induced Neurotoxicity 18 71.00 Quite High
Stress 6 43.92 Quite Low
Hepatotoxicity 15 35.52 Quite Low
Overdose 27 5.00 Very Low Very Low Very Low
Acute Liver Failure 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, AAP induced an increase in CYP2E1 expression as indicated by the rise in CYP2E1 protein levels (Figure 6B).
AAP Positive_regulation (increase) of Gene_expression (expression) of CYP2E1 associated with paracetamol
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.60 Pain Relevance 1.32
Since AAP is found unaltered in the brain and AAP increases CYP2E1 expression and activity, AAP could induce cortical neuron apoptosis due to increased local NAPQI production through CYP2E1 enzymatic activity.
AAP Positive_regulation (increases) of Gene_expression (expression) of CYP2E1 in neuron associated with paracetamol and apoptosis
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.46 Pain Relevance 1.04
Blocking the mitochondrial permeability transition using bongkrekic acid prevented an AAP-mediated increase in CYP2E1 expression (Figure 6C).


AAP-mediated Positive_regulation (increase) of Gene_expression (expression) of CYP2E1 associated with paracetamol
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.50 Pain Relevance 1.24

General Comments

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