INT349584

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.56
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
neuronal 2
Cyp2e1 (Rattus norvegicus)
Aap (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 498 100.00 Very High Very High Very High
Dopamine 3 35.12 Quite Low
cINOD 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 57 99.96 Very High Very High Very High
Drug Induced Neurotoxicity 18 99.48 Very High Very High Very High
Death 138 99.16 Very High Very High Very High
Hepatotoxicity 15 84.80 Quite High
Overdose 27 72.12 Quite High
Liver Failure 3 71.16 Quite High
Stress 6 67.36 Quite High
Apoptosis 48 50.00 Quite Low
Alzheimer's Dementia 3 22.64 Low Low
Acute Liver Failure 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP2E1 is the most important P-450 isoenzyme involved in AAP metabolism, although other isoforms like CYP1A2 or CYP3A might also be involved [37].
CYP2E1 Spec (might) Binding (metabolism) of AAP associated with paracetamol
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.44 Pain Relevance 0.96
To analyse whether metabolism through CYP2E1 was involved in the AAP toxicity mechanism, we determined the effect of TTD on AAP-induced neuronal death.
CYP2E1 Spec (whether) Binding (metabolism) of AAP in neuronal associated with toxicity, paracetamol and death
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.58 Pain Relevance 1.10
AAP metabolism by CYP2E1 plays a key role in neuronal toxicity
CYP2E1 Binding (metabolism) of AAP in neuronal associated with toxicity and paracetamol
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.54 Pain Relevance 1.17

General Comments

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