INT349589

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.84
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
neurons 2
neuronal 1
Aap (Mus musculus)
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 664 100.00 Very High Very High Very High
Pain 12 62.68 Quite High
imagery 12 47.20 Quite Low
cINOD 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Liver Failure 16 99.60 Very High Very High Very High
Death 184 96.40 Very High Very High Very High
Overdose 36 91.88 High High
Toxicity 76 82.28 Quite High
Syndrome 8 79.28 Quite High
Stroke 12 76.44 Quite High
Apoptosis 64 75.00 Quite High
Encephalopathy 12 72.64 Quite High
Hepatotoxicity 20 69.36 Quite High
Fever 8 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that CYP2E1 is constitutively expressed in the brain and is induced by different drugs, including AAP, [69], [70] and that AAP is mainly metabolised by the 2E1 isoform of cytochrome P-450 [7] suggests that the P-450 enzymatic activity observed in treated neurons corresponds to the CYP2E1isoform.


AAP Positive_regulation (induced) of CYP2E1 in neurons associated with paracetamol
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.08 Pain Relevance 0.34
The fact that CYP2E1 is constitutively expressed in the brain and is induced by different drugs, including AAP, [69], [70] and that AAP is mainly metabolised by the 2E1 isoform of cytochrome P-450 [7] suggests that the P-450 enzymatic activity observed in treated neurons corresponds to the CYP2E1isoform.


AAP Positive_regulation (induced) of CYP2E1 in neurons associated with paracetamol
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.08 Pain Relevance 0.34
To determine if this increase in ROS production was related to AAP-induced CYP2E1 activity and caused a decrease in GSH levels, we studied the effect of NAC and of the CYP2E1 inhibitor TTD.
AAP Positive_regulation (induced) of CYP2E1 associated with paracetamol
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.32 Pain Relevance 0.88
AAP also increases both neuronal cytochrome P450 isoform CYP2E1 enzymatic activity and protein levels as determined by Western blot, leading to neuronal death through mitochondrial–mediated mechanisms that involve cytochrome c release and caspase 3 activation.
AAP Positive_regulation (increases) of P450 isoform CYP2E1 in neuronal associated with paracetamol and death
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3000821 Disease Relevance 1.36 Pain Relevance 1.15

General Comments

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