INT349608

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.41
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LMOD1) small molecule metabolic process (DIO2) cytoskeleton (LMOD1)
plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2) cytoplasm (LMOD1)
Anatomy Link Frequency
joint 1
DIO2 (Homo sapiens)
LMOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 368 100.00 Very High Very High Very High
antagonist 136 98.64 Very High Very High Very High
agonist 128 98.42 Very High Very High Very High
dopamine receptor 36 95.46 Very High Very High Very High
Neurotransmitter 20 67.44 Quite High
Substantia nigra 16 5.00 Very Low Very Low Very Low
deep brain stimulation 8 5.00 Very Low Very Low Very Low
Thalamus 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscle Hypotonia 8 98.84 Very High Very High Very High
Hyperkinesis 8 98.00 Very High Very High Very High
Parkinson's Disease 56 88.00 High High
Basal Ganglia Disease 4 65.92 Quite High
Targeted Disruption 8 57.64 Quite High
Disease 20 44.48 Quite Low
Dyskinesias 64 42.16 Quite Low
Hypokinesia 48 36.88 Quite Low
Muscle Rigidity 16 23.84 Low Low
Movement Disorders 28 5.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our model is based on recent findings and statements that (Obeso et al. 2008) nigrostriatal somatotopy is organized as the same nigrostriatal projections innervate the antagonist muscle pairs around the same joint (Smith and Villalba 2008); postsynaptic functionally active D1 and D2 dopamine receptors are simultaneously innervated by the singular nigrostriatal axon within the striatal locus somatotopically responsible for motor control in agonist/antagonist muscle pair around the given joint (Bertran-Gonzalez et al. 2008); D1 receptors interact with nanomolar and D2 with micromolar concentration of dopamine.
D2 Binding (interact) of D1 in joint associated with dopamine, dopamine receptor, antagonist and agonist
1) Confidence 0.23 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.12 Pain Relevance 0.35
During the rise of dopamine concentration the D1 receptors interact with lower dopamine concentrations than D2 so that the D1-mediated tone inhibition must occur before D2-promoted acceleration of contraction.
D2 Binding (interact) of D1 associated with dopamine
2) Confidence 0.23 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0 Pain Relevance 0.56
D1 receptors interact with lower and D2 receptors with higher dopamine concentrations.
D2 Binding (interact) of D1 associated with dopamine
3) Confidence 0.20 Published 2010 Journal J Neural Transm Section Abstract Doc Link PMC3000910 Disease Relevance 0 Pain Relevance 0.46
The interaction between dopamine and striatal D1- and D2-receptors occurs simultaneously with tone and contraction modulation during movement leading one to consider that D1 and D2 may be distinguished in tone and contraction regulation on the follow manner:

Dopamine-dependent tone and contraction regulation

D2 Binding (interaction) of D1 associated with dopamine
4) Confidence 0.18 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.28 Pain Relevance 0.63

General Comments

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