INT349613

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LMOD1) cytoskeleton (LMOD1) cytoplasm (LMOD1)
Anatomy Link Frequency
neurons 2
LMOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 64 97.20 Very High Very High Very High
antagonist 68 96.88 Very High Very High Very High
dopamine receptor 18 89.36 High High
Dopamine 184 87.84 High High
Thalamus 4 77.48 Quite High
positron emission tomography 2 69.36 Quite High
Substantia nigra 8 58.08 Quite High
Neurotransmitter 10 43.28 Quite Low
deep brain stimulation 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Movement Disorders 14 98.32 Very High Very High Very High
Tremor 22 84.04 Quite High
Hypokinesia 24 71.00 Quite High
Parkinson's Disease 28 49.04 Quite Low
Hyperkinesis 4 29.04 Quite Low
Muscle Hypotonia 4 27.68 Quite Low
Dyskinesias 32 5.00 Very Low Very Low Very Low
Dystonia 18 5.00 Very Low Very Low Very Low
Tics 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus the single nigral axon may influence both D1 and D2 receptors in the pool of striatal neurons responsible for movement activity of agonist–antagonist muscle pair.
Spec (may) Regulation (influence) of D1 Binding (receptors) of in neurons associated with antagonist and agonist
1) Confidence 0.41 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0 Pain Relevance 0.49
At the molecular biology and neuropharmacological levels, the hypothesis suggests that putative treatments need to consider both D1 and D2 activity for maximal therapeutic efficacy in most movement disorders.



Regulation (consider) of D1 Binding (activity) of associated with movement disorders
2) Confidence 0.36 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.53 Pain Relevance 0.25

General Comments

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