INT349657

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nos2, Nos1) cytosol (Nos2, Nos1) oxidoreductase activity (Nos2, Nos1)
nucleus (Nos2, Nos1) mitochondrion (Nos1) peroxisome (Nos2)
Anatomy Link Frequency
spinal cord 2
Nos2 (Mus musculus)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 77 100.00 Very High Very High Very High
Spinal cord 53 100.00 Very High Very High Very High
Neuropathic pain 22 97.26 Very High Very High Very High
Thermal hyperalgesia 16 81.76 Quite High
allodynia 31 80.32 Quite High
Pain 7 50.00 Quite Low
isoflurane 1 10.72 Low Low
anesthesia 1 9.84 Low Low
withdrawal 11 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 98 99.54 Very High Very High Very High
Neuropathic Pain 55 97.26 Very High Very High Very High
Hyperalgesia 17 81.76 Quite High
Nervous System Injury 32 15.44 Low Low
Nociception 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data also indicate that: i) the increased spinal cord expression of NOS1 plays a critical role in the maintenance of peripheral neuropathic pain, ii) a compensatory up-regulation of NOS2 isoform takes place in the spinal cord of sciatic nerve-injured NOS1-KO mice, and iii) the up-regulation of NOS1 in the spinal cord of sciatic nerve-injured WT mice at 21 days after surgery is modulated by NOS2.


NOS2 Regulation (modulated) of Regulation (regulation) of NOS1 in spinal cord associated with targeted disruption, neuropathic pain, sciatic nerve and spinal cord
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.90 Pain Relevance 0.80

General Comments

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