INT349658

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.86
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nos2, Nos1) cytosol (Nos2, Nos1) oxidoreductase activity (Nos2, Nos1)
nucleus (Nos2, Nos1) mitochondrion (Nos1) peroxisome (Nos2)
Anatomy Link Frequency
spinal cord 4
Nos2 (Mus musculus)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 106 99.98 Very High Very High Very High
Sciatic nerve 154 99.10 Very High Very High Very High
allodynia 62 98.04 Very High Very High Very High
Thermal hyperalgesia 32 97.60 Very High Very High Very High
Neuropathic pain 44 97.40 Very High Very High Very High
Pain 14 75.00 Quite High
withdrawal 22 5.00 Very Low Very Low Very Low
IPN 4 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 110 98.04 Very High Very High Very High
Hyperalgesia 34 97.60 Very High Very High Very High
Targeted Disruption 196 87.76 High High
Nervous System Injury 64 83.60 Quite High
Syndrome 2 74.80 Quite High
Pain 14 46.96 Quite Low
Hypersensitivity 6 42.16 Quite Low
Nociception 16 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Inflammatory Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study demonstrates for first time the participation of NOS1 and NOS2 in the development and maintenance of thermal hyperalgesia and thermal allodynia induced by the chronic constriction of sciatic nerve and suggests that the increased spinal cord expression of NOS1 is regulated by NOS2, and might be responsible for the maintenance of chronic peripheral neuropathic pain in mice.
NOS2 Regulation (regulated) of Gene_expression (expression) of NOS1 in spinal cord associated with allodynia, thermal hyperalgesia, neuropathic pain, sciatic nerve and spinal cord
1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.34 Pain Relevance 0.87
These data suggest that the increased spinal cord expression of NOS1, regulated by NOS2, might be responsible for the maintenance of chronic peripheral neuropathic pain in mice and propose these enzymes as interesting therapeutic targets for their treatment.



NOS2 Regulation (regulated) of Gene_expression (expression) of NOS1 in spinal cord associated with neuropathic pain and spinal cord
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.52 Pain Relevance 0.97

General Comments

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