INT349668

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HRH1, PYCARD) cytosol (PYCARD) signal transduction (PYCARD)
nucleolus (HRH1) intracellular (PYCARD) plasma membrane (HRH1)
HRH1 (Homo sapiens)
PYCARD (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 2 100.00 Very High Very High Very High
Inflammation 6 90.00 High High
agonist 80 80.72 Quite High
Potency 10 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
beta blocker 4 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 22 95.72 Very High Very High Very High
Asthma 38 95.36 Very High Very High Very High
Disease 12 90.84 High High
INFLAMMATION 6 90.00 High High
Airway Obstruction 8 31.96 Quite Low
Stress 8 5.00 Very Low Very Low Very Low
Heart Rate Under Development 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Anxiety 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous research had demonstrated that Asc binds directly to the histamine receptor on the first extracellular loop [4], so our hypothesis was that a similar extracellular loop on the B2AR might also exist.
histamine receptor Binding (binds) of Asc
1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0
In light of the receptor mechanism suggested above for Asc enhancement of adrenergic function, and since Asc modifies dopamine binding to its receptors [1], [18] and binds to the first extracellular loop of the histamine receptor [4], it was logical to search for an Asc binding site on the AR that could act allosterically to modify receptor sensitivity.
histamine receptor Binding (binds) of Asc associated with dopamine
2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0.37 Pain Relevance 0.21

General Comments

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