INT349722

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr3) intracellular (Egr3) DNA binding (Egr3)
Anatomy Link Frequency
striatum 2
Egr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 106 99.82 Very High Very High Very High
nMDA receptor 1 64.48 Quite High
Glutamate 4 58.80 Quite High
agonist 12 29.44 Quite Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Dynorphin 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the steady-state increases in DA released in the synaptic cleft of the 6-OHDA-treated animals might cause potentiated transcriptional sensitivity to METH-mediated DA-induced changes in Egr2 and Egr3 expression in the intact striatum.


Regulation (changes) of Gene_expression (expression) of Egr3 in striatum associated with dopamine
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.39

General Comments

This test has worked.

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