INT349725

Context Info Confidence 0.63 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.13 Pain Relevance 0.53

extracellular region (Fst) nucleus (Fst) cellular_component (Fst) cytoplasm (Fst)

Fst (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 212 99.36 Neuropeptide 6 91.36 Nucleus accumbens 4 81.92 Substantia nigra 4 81.00 Hippocampus 2 58.64 cerebral cortex 2 58.12 medulla 2 54.24 Neurotransmitter 12 52.32 ischemia 2 44.16 Spinal cord 2 35.92

Disease Link Frequency Relevance Heat Body Weight 2 68.16 Nociception 2 66.60 Cv Unclassified Under Development 2 44.16 Disease 6 5.00 Gliosis 2 5.00 Drug Dependence 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The observations that the small METH dose caused further increases in Fst mRNA levels on the lesioned side of 6-OHDA-treated rats suggest that these METH-induced alterations in Fst expression might be independent of METH-induced DA release.

Transcription (levels) of Fst associated with dopamine

1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.22

The DA depletion-induced increases in Fst mRNA levels are consistent with those reported in a recent microarray study [44].

Transcription (levels) of Fst associated with dopamine

2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0.13 Pain Relevance 0.31

General Comments

This test has worked.