INT349753

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.88
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Galr1) plasma membrane (Galr1) signal transducer activity (Galr1)
Galr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 44 91.00 High High
Neuronal excitability 10 90.24 High High
antagonist 30 87.76 High High
Glutamate 12 86.16 High High
Neuropeptide 4 76.36 Quite High
Pain 2 42.60 Quite Low
Neurotransmitter 2 29.00 Quite Low
Pyramidal cell 14 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 99.62 Very High Very High Very High
Death 80 99.14 Very High Very High Very High
Convulsion 128 98.76 Very High Very High Very High
Status Epilepticus 14 98.32 Very High Very High Very High
Sprains And Strains 24 68.16 Quite High
Toxicity 4 65.68 Quite High
Injury 18 63.04 Quite High
Pain 2 42.60 Quite Low
Neurodegenerative Disease 4 37.92 Quite Low
Epilepsy 28 35.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to test more formally the potential influence of GalR1 on seizure-induced excitotoxic cell death, we conducted functional complementation tests in which transgenic mice that exhibit decreased expression of the GalR1 candidate mRNA underwent kainate-induced status epilepticus to determine if the quantitative trait of susceptibility to seizure-induced cell death is determined by the activity of GalR1.
Negative_regulation (decreased) of Transcription (expression) of GalR1 associated with targeted disruption, convulsion, status epilepticus and death
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001489 Disease Relevance 0.85 Pain Relevance 0.17
In order to test more formally the potential influence of GalR1 on seizure-induced excitotoxic cell death, we have conducted functional complementation tests in which we determined if there are functional differences in susceptibility to seizure-induced cell death by utilizing transgenic mice that exhibit decreased expression of the GalR1 candidate mRNA.
Negative_regulation (decreased) of Transcription (expression) of GalR1 associated with targeted disruption, convulsion and death
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 1.03 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox