INT34976

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Context Info
Confidence 0.43
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.21
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1) mitochondrion organization (OPA1) GTPase activity (OPA1)
Anatomy Link Frequency
heart 2
OPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 3 85.44 High High
cva 54 85.36 High High
transdermal 2 75.00 Quite High
Angina 2 75.00 Quite High
tolerance 1 75.00 Quite High
ischemia 1 53.88 Quite High
Serotonin 5 41.92 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Tension Glaucoma 72 100.00 Very High Very High Very High
Glaucoma 70 100.00 Very High Very High Very High
Disease 8 100.00 Very High Very High Very High
Retinal Vein Occlusion 77 99.92 Very High Very High Very High
Optic Disorders 4 98.08 Very High Very High Very High
Obesity 59 97.04 Very High Very High Very High
Increased Venous Pressure Under Development 20 91.60 High High
Depression 3 85.44 High High
Hemorrhage 50 85.36 High High
Cv General 3 Under Development 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peak exercise heart rate and pressure rate product were both significantly higher on TTS NTG, as well as on nifedipine, in comparison with placebo, while values after verapamil did not differ from those after placebo.
Positive_regulation (on) of Gene_expression (higher) of NTG in heart
1) Confidence 0.43 Published 1986 Journal G Ital Cardiol Section Abstract Doc Link 3104124 Disease Relevance 0.13 Pain Relevance 0.21
Since NTG is a chronically progressing disease, these findings imply that patients had NTG before BRVO, and correspond with the results of earlier studies.27
Positive_regulation (Since) of Gene_expression (disease) of NTG associated with low tension glaucoma, disease and retinal vein occlusion
2) Confidence 0.42 Published 2007 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2629887 Disease Relevance 2.57 Pain Relevance 0.12
Measurements of aix after salbutamol or ntg administration
Positive_regulation (Measurements) of Gene_expression (administration) of ntg
3) Confidence 0.04 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815836 Disease Relevance 0.28 Pain Relevance 0
Whilst Puustjarvi et al reported that the level of serum vitamin B6 does not differ statistically between the PXG and control groups,34 Roedl et al found that levels of vitamin B6 were significantly lower in their PXG patients.35 Vitamin B6, which is a cofactor in the catabolism of Hcy, increased in the POAG and NTG groups, whilst it is in the normal range in the PXG group.
Positive_regulation (increased) of Gene_expression (groups) of NTG associated with low tension glaucoma and glaucoma
4) Confidence 0.02 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2861848 Disease Relevance 1.23 Pain Relevance 0.07

General Comments

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