INT34978

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Hmga2) enzyme binding (Hmga2) DNA binding (Hmga2)
mitosis (Hmga2) signal transduction (Hmga2) nucleus (Hmga2)
Anatomy Link Frequency
pituitary 4
Hmga2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain threshold 2 100.00 Very High Very High Very High
cINOD 3 89.68 High High
Analgesic 5 88.44 High High
Hyperalgesia 3 75.00 Quite High
Morphine 1 73.04 Quite High
central pain 1 42.56 Quite Low
Central nervous system 1 39.76 Quite Low
Pain 2 25.00 Low Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 54 100.00 Very High Very High Very High
Targeted Disruption 22 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
INFLAMMATION 1 91.60 High High
Hyperalgesia 8 83.28 Quite High
Cancer 6 65.80 Quite High
Adenoma 8 46.08 Quite Low
Retinoblastoma 4 15.16 Low Low
Prolactinoma 6 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistently, HDAC1 activity associated to pRB is lower in cells and pituitary adenomas overexpressing HMGA2 than in mock-transfected cells and normal pituitary, respectively [38].
Negative_regulation (lower) of Gene_expression (overexpressing) of HMGA2 in pituitary associated with pituitary cancer
1) Confidence 0.42 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.23 Pain Relevance 0
The doses that produced the maximal decrease in pain threshold for arachidonic acid, PG E2, PG F2 alpha and PG D2 were 10 micrograms/mouse, 10 ng/mouse, 100 ng/mouse and 100 ng/mouse, respectively.
Negative_regulation (decrease) of Gene_expression (produced) of PG D2 associated with pain threshold
2) Confidence 0.42 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3104573 Disease Relevance 0.87 Pain Relevance 0.95
Suppression of pituitary tumorigenesis in HMGA2 transgenic mice lacking E2F1
Negative_regulation (Suppression) of Gene_expression (transgenic mice) of HMGA2 in pituitary associated with targeted disruption
3) Confidence 0.42 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.43 Pain Relevance 0

General Comments

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