INT349820

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.99
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
neurons 4
Hspb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 24 78.72 Quite High
dorsal root ganglion 18 74.80 Quite High
Peripheral nerve injury 3 71.52 Quite High
Spinal cord 51 50.20 Quite High
Inflammatory response 18 5.00 Very Low Very Low Very Low
Neuropeptide 15 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 15 99.00 Very High Very High Very High
Spinal Cord Injury 87 93.00 High High
Death 36 90.88 High High
Injury 105 87.60 High High
Apoptosis 72 85.40 High High
INFLAMMATION 42 78.72 Quite High
Ganglion Cysts 21 73.84 Quite High
Nervous System Injury 3 70.64 Quite High
Spinal Injuries 24 39.64 Quite Low
Contusions 18 27.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An examination of the genes involved in cell stress/neuroprotection and axonal regeneration revealed a consistent up-regulation of Atf3, but only a transient up-regulation of Hspb1 (Hsp27) in LDPT neurons post-axotomy.
Regulation (regulation) of Regulation (regulation) of Hsp27 in neurons associated with stress
1) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.21 Pain Relevance 0.15
An examination of the genes involved in cell stress/neuroprotection and axonal regeneration revealed a consistent up-regulation of Atf3, but only a transient up-regulation of Hspb1 (Hsp27) in LDPT neurons post-axotomy.
Regulation (regulation) of Regulation (regulation) of Hspb1 in neurons associated with stress
2) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.21 Pain Relevance 0.15
There was a lack of a significant regenerative response, with the exception of an up-regulation of Atf3 and early up-regulation of Hspb1 (Hsp27), both involved in cell stress/neuroprotection as well as axonal regeneration.
Regulation (regulation) of Neg (exception) Regulation (regulation) of Hsp27 associated with stress
3) Confidence 0.21 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC3001741 Disease Relevance 0.57 Pain Relevance 0.03

General Comments

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