INT349853

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.30
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb1, Jun) cytosol (Jun) aging (Jun)
plasma membrane (Hspb1) cytoskeleton (Hspb1) intracellular (Hspb1)
Anatomy Link Frequency
neuronal 2
Hspb1 (Rattus norvegicus)
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 12 92.32 High High
Peripheral nerve injury 2 91.68 High High
Inflammation 16 87.64 High High
Spinal cord 34 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Neuropeptide 10 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 48 99.76 Very High Very High Very High
Ganglion Cysts 14 92.32 High High
Nervous System Injury 2 91.68 High High
INFLAMMATION 28 87.64 High High
Targeted Disruption 2 87.20 High High
Injury 70 87.00 High High
Stress 10 71.08 Quite High
Spinal Cord Injury 58 66.72 Quite High
Death 24 45.08 Quite Low
Spinal Injuries 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hsp27 is a downstream product of the dimerisation of ATF-3 and c-Jun, another transcription factor usually up-regulated after axotomy [53] that was not examined in the current study. c-Jun has been associated with apoptosis, neuronal survival, as well as regeneration [53].
Hsp27 Binding (associated) of Jun in neuronal associated with apoptosis
1) Confidence 0.14 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.15 Pain Relevance 0.23
Hsp27 is a downstream product of the dimerisation of ATF-3 and c-Jun, another transcription factor usually up-regulated after axotomy [53] that was not examined in the current study. c-Jun has been associated with apoptosis, neuronal survival, as well as regeneration [53].
Hsp27 Binding (associated) of Jun in neuronal associated with apoptosis
2) Confidence 0.11 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.15 Pain Relevance 0.23

General Comments

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