INT349935

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.22
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
Anatomy Link Frequency
hearts 4
CYP1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 5 71.64 Quite High
Inflammation 10 53.36 Quite High
Calcium channel 10 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 45 98.82 Very High Very High Very High
Disease 10 84.24 Quite High
Reperfusion Injury 5 72.40 Quite High
Cv Unclassified Under Development 5 71.64 Quite High
Increased Venous Pressure Under Development 10 59.92 Quite High
INFLAMMATION 10 53.36 Quite High
Fibrosis 5 51.60 Quite High
Apoptosis 5 40.56 Quite Low
Coronary Heart Disease 5 37.36 Quite Low
Cardiovascular Disease 15 35.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP4A11, CYP2E1, CYP1A1 and CYP2C8 mRNAs were present at an intermediate level while CYP2B6 and CYP2C9 mRNAs were present at very low levels in some of the analyzed hearts.


Transcription (present) of CYP1A1 in hearts
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.07 Pain Relevance 0
When information is available, it is based on a small number (often <10) of explanted hearts from subjects with various conditions.[10], [11], [12], [13] For instance, Thum and Borlak report the presence of CYP1A1, CYP2B6, CYP2C8, CYP2C19, CYP2D6 and CYP4B1 mRNAs in seven explanted hearts.
Transcription (presence) of CYP1A1 in hearts
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.19 Pain Relevance 0.03
68) of explanted left ventricular heart samples from patients with end-stage heart failure undergoing cardiac transplant; 2) to compare the relative CYP1-4 mRNA levels in samples from ischemic and non-ischemic hearts; 3) to compare the relative CYP1-4 mRNA levels in left and right ventricular tissues in selected subjects (n?
Transcription (levels) of CYP1 in hearts associated with myocardial infarction
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.27 Pain Relevance 0.03
68) of explanted left ventricular heart samples from patients with end-stage heart failure undergoing cardiac transplant; 2) to compare the relative CYP1-4 mRNA levels in samples from ischemic and non-ischemic hearts; 3) to compare the relative CYP1-4 mRNA levels in left and right ventricular tissues in selected subjects (n?
Transcription (levels) of CYP1 in hearts associated with myocardial infarction
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.33 Pain Relevance 0.03
In this light, the objectives of our study were: 1) to determine the relative levels of CYP450 mRNAs (CYP1, CYP2, CYP3 and CYP4 families) in a large cohort (n?
Spec (determine) Transcription (levels) of CYP1
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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