INT349979

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 4.34
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CCKBR) plasma membrane (CCKBR) nucleus (CCKBR)
cytoplasm (CCKBR) signal transducer activity (CCKBR)
CCKBR (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 120 68.44 Quite High
Calcium channel 40 5.00 Very Low Very Low Very Low
medulla 24 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
amygdala 8 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Deafferentation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Deafness 120 98.96 Very High Very High Very High
Tinnitus 768 98.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 82.96 Quite High
Anxiety Disorder 72 81.92 Quite High
Hyperacusis 24 62.88 Quite High
Death 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Aging 8 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low
Brain Injury 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using inhibition of startle techniques, pASR and gASR, we were able to correlate a decrease in the ability to inhibit the ASR at specific frequencies with the perception of tinnitus.
Negative_regulation (inhibition) of gASR associated with tinnitus
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.73 Pain Relevance 0.03
For noise-exposed animals, the ability to inhibit the gASR remained decreased at both time points following noise exposure (Figure 6).
Negative_regulation (inhibit) of gASR
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.61 Pain Relevance 0.03
However, the salicylate group showed a decreased ability to inhibit gASR one hour after salicylate treatment, but by seven hours the ability to attenuate gASR had returned to normal levels.
Negative_regulation (inhibit) of gASR
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.53 Pain Relevance 0.03
When tested for inhibition of gASR, there was a significant reduction in the ability to inhibit the acoustic startle reflex at both post-noise time points at the frequencies of 12 (baseline – 28%, 24 hrs – 16% p?
Negative_regulation (inhibition) of gASR
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.43 Pain Relevance 0
However, the salicylate group showed a decreased ability to inhibit gASR one hour after salicylate treatment, but by seven hours the ability to attenuate gASR had returned to normal levels.
Negative_regulation (attenuate) of gASR
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.59 Pain Relevance 0.03
Control animals showed a robust attenuation of both the pASR and the gASR regardless of the frequency that was tested (Figure 3).
Negative_regulation (attenuation) of gASR
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.11 Pain Relevance 0.03
For each animal both pre-pulse inhibition (pASR) and gap detection inhibition (gASR) of acoustic startle was conducted.
Negative_regulation (inhibition) of gASR
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.30 Pain Relevance 0.06
Six hours after the last salicylate injection, gASR inhibition was not significantly different from baseline, likely reflecting the decrease in systemic salicylate and therefore decreased tinnitus perception.
Negative_regulation (inhibition) of gASR associated with tinnitus
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 1.05 Pain Relevance 0

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