INT350

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Context Info
Confidence 0.80
First Reported 1979
Last Reported 2010
Negated 1
Speculated 9
Reported most in Abstract
Documents 79
Total Number 88
Disease Relevance 10.26
Pain Relevance 41.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 8
medulla 4
locus coeruleus 3
muscle 2
arcuate nucleus 2
Th (Rattus norvegicus)
Th - L8Y (1)
Pain Link Frequency Relevance Heat
Enkephalin 234 100.00 Very High Very High Very High
Dopamine 129 100.00 Very High Very High Very High
substance P 105 100.00 Very High Very High Very High
Catecholamine 85 100.00 Very High Very High Very High
Neuropeptide 83 100.00 Very High Very High Very High
Serotonin 52 100.00 Very High Very High Very High
Glutamate 33 100.00 Very High Very High Very High
Somatostatin 26 100.00 Very High Very High Very High
Calcitonin gene-related peptide 21 100.00 Very High Very High Very High
Cholecystokinin 16 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 100.00 Very High Very High Very High
Holoprosencephaly 9 99.76 Very High Very High Very High
Ganglion Cysts 65 99.16 Very High Very High Very High
Celiac Disease 9 98.72 Very High Very High Very High
Obesity 17 98.28 Very High Very High Very High
Nociception 14 96.28 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 95.96 Very High Very High Very High
Increased Venous Pressure Under Development 12 95.36 Very High Very High Very High
Opiate Addiction 2 93.52 High High
Hypoxia 62 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of tissue samples with specific polyclonal antibodies and 125I-protein A, followed by autoradiography, allows the permanent recording of the radioimmunohistochemical localization of brain methionine-enkephalin, tyrosine hydroxylase, and angiotensin-converting enzyme and of pituitary vasopressin and could be applied to the localization of many other tissue antigens. 4.
Localization (localization) of tyrosine hydroxylase in brain associated with enkephalin
1) Confidence 0.80 Published 1988 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 3401900 Disease Relevance 0 Pain Relevance 0.26
Immunocytochemical localization of tyrosine hydroxylase in rat adrenal medulla by the peroxidase labeled antibody method: effects of enzyme activation on ultrastructural distribution of the enzyme.
Localization (localization) of tyrosine hydroxylase in adrenal medulla associated with medulla
2) Confidence 0.79 Published 1981 Journal Brain Res. Section Title Doc Link 6112040 Disease Relevance 0.36 Pain Relevance 0.30
In vivo measurements, Falck-Hillarp histochemistry using iris whole mounts to assess catecholamine fiber outgrowth and immunocytochemical localization of tyrosine hydroxylase (TH-), neuropeptide Y (NPY-), leu-enkephalin (ENK-) and calcitonin gene-related peptide (CGRP-) like immunoreactivity (LI) were used.
Localization (localization) of TH- in iris associated with catecholamine, neuropeptide, enkephalin and calcitonin gene-related peptide
3) Confidence 0.78 Published 1991 Journal Exp Brain Res Section Abstract Doc Link 1679395 Disease Relevance 0.13 Pain Relevance 0.45
Immunohistochemical colocalization of Met5-enkephalin-Arg6-Gly7-Leu8 with tyrosine hydroxylase in neurons of the porcine inferior mesenteric and coeliac-superior mesenteric ganglia.
Localization (colocalization) of tyrosine hydroxylase (L8Y) in neurons associated with celiac disease and enkephalin
4) Confidence 0.76 Published 1994 Journal Folia Histochem. Cytobiol. Section Title Doc Link 7758615 Disease Relevance 0.48 Pain Relevance 0.19
Thus, biotinylated dextran amine (BDA) was iontophoretically injected into the ventral medulla and single-tissue sections were processed for peroxidase localization of BDA and gold-silver labeling of tyrosine hydroxylase (TH).
Localization (localization) of TH in medulla associated with medulla
5) Confidence 0.75 Published 1998 Journal Brain Res. Section Abstract Doc Link 9518578 Disease Relevance 0 Pain Relevance 0.49
Localization of bombesin-, neuropeptide Y-, enkephalin- and tyrosine hydroxylase-like immunoreactivities in rat coeliac-superior mesenteric ganglion.
Localization (Localization) of tyrosine hydroxylase in superior mesenteric ganglion associated with ganglion cysts, celiac disease, neuropeptide and enkephalin
6) Confidence 0.75 Published 1989 Journal Histochemistry Section Title Doc Link 2570773 Disease Relevance 0.60 Pain Relevance 0.39
Electron microscopy of the m-NTS at the level of the area postrema further established the single as well as dual localization of TH and LE-LI in individual perikarya, dendrites, and axon terminals.
Localization (localization) of TH in dendrites
7) Confidence 0.75 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2568412 Disease Relevance 0.09 Pain Relevance 0.78
Single sections were dually labeled using a double-bridged peroxidase method for the localization of a monoclonal leucine (Leu5)-enkephalin-antibody and immunoautoradiography for the localization of polyclonal antibodies against the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH).
Localization (localization) of TH associated with catecholamine and enkephalin
8) Confidence 0.75 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2568412 Disease Relevance 0.10 Pain Relevance 0.86
Light and electron microscopic localization of enkephalin and tyrosine hydroxylase in neostriatum of fetal and adult rat brain.
Localization (localization) of tyrosine hydroxylase in brain associated with enkephalin
9) Confidence 0.74 Published 1981 Journal Acta Histochem. Suppl. Section Title Doc Link 6112776 Disease Relevance 0 Pain Relevance 0.38
In fetal rat brain, immunocytochemical localization of tyrosine hydroxylase and methionine (Met5)-enkephalin demonstrates that dopaminergic axons labeled with the biosynthetic enzyme can be detected in th neostriatum prior to the appearance of the peptide in neuronal perikarya.
Localization (localization) of tyrosine hydroxylase in neuronal associated with enkephalin
10) Confidence 0.74 Published 1981 Journal Acta Histochem. Suppl. Section Abstract Doc Link 6112776 Disease Relevance 0 Pain Relevance 0.25
The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.
Localization (localization) of TH in peptidergic neurons associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
11) Confidence 0.73 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.41
Surgically denervated IWAT and EWAT showed significantly decreased tyrosine hydroxylase-ir and CGRP-ir, whereas capsaicin-treated WAT had only significantly decreased CGRP-ir.
Localization (decreased) of tyrosine hydroxylase in WAT associated with qutenza, obesity and calcitonin gene-related peptide
12) Confidence 0.73 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15550613 Disease Relevance 1.41 Pain Relevance 0.37
To better define the cellular sites for the physiological activation of mu OR in the LC and its relation to afferent terminals, we examined the ultrastructural localization of mu OR immunoreactivity in sections dually labeled for the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH).
Spec (examined) Localization (localization) of TH associated with catecholamine and locus ceruleus
13) Confidence 0.73 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8756434 Disease Relevance 0.09 Pain Relevance 0.89
Thus, biotinylated dextran amine (BDA) was iontophoretically injected into the ventral medulla and single-tissue sections were processed for peroxidase localization of BDA and gold-silver labeling of tyrosine hydroxylase (TH).
Localization (localization) of tyrosine hydroxylase in medulla associated with medulla
14) Confidence 0.70 Published 1998 Journal Brain Res. Section Abstract Doc Link 9518578 Disease Relevance 0 Pain Relevance 0.49
We examined the dual immunocytochemical localization of antisera raised against Leu5-enkephalin and the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), to determine the cellular substrates for these and/or other functional interactions.
Spec (examined) Localization (localization) of tyrosine hydroxylase associated with catecholamine and enkephalin
15) Confidence 0.70 Published 1992 Journal J. Neurosci. Res. Section Abstract Doc Link 1349353 Disease Relevance 0 Pain Relevance 0.48
Immunohistochemical localization of tyrosine hydroxylase (TH), a marker for sympathetic nerve fibres, revealed that the capsaicin-induced hyperinnervation was mainly represented by fibres in deeper muscle layers and to a smaller extent by fibres in the submucosa.
Localization (localization) of TH in muscle associated with qutenza
16) Confidence 0.69 Published 1998 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 9808370 Disease Relevance 0 Pain Relevance 0.87
The morphological support of interactions between enkephalins and three systems--beta-endorphin (beta-END), tyrosine hydroxylase (TH), or neuropeptide Y (NPY)--well represented in the arcuate nucleus, was examined by using an electron microscopic double immunostaining combining two sensitive chromogens, diaminobenzidine (DAB) and tetramethylbenzidine (TMB).
Localization (represented) of TH in arcuate nucleus associated with neuropeptide and enkephalin
17) Confidence 0.69 Published 1994 Journal Peptides Section Abstract Doc Link 7984509 Disease Relevance 0 Pain Relevance 0.15
The morphological support of interactions between enkephalins and three systems--beta-endorphin (beta-END), tyrosine hydroxylase (TH), or neuropeptide Y (NPY)--well represented in the arcuate nucleus, was examined by using an electron microscopic double immunostaining combining two sensitive chromogens, diaminobenzidine (DAB) and tetramethylbenzidine (TMB).
Localization (represented) of tyrosine hydroxylase in arcuate nucleus associated with neuropeptide and enkephalin
18) Confidence 0.69 Published 1994 Journal Peptides Section Abstract Doc Link 7984509 Disease Relevance 0 Pain Relevance 0.15
The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.
Localization (localization) of tyrosine hydroxylase in peptidergic neurons associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
19) Confidence 0.68 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.41
The nerve terminals in the intermediate and posterior lobes of the rat pituitary gland are reported to show colocalization of serotonin and tyrosine hydroxylase.
Localization (colocalization) of tyrosine hydroxylase in posterior lobes associated with serotonin
20) Confidence 0.68 Published 1995 Journal Brain Res. Section Abstract Doc Link 7712183 Disease Relevance 0 Pain Relevance 0.17

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