INT3500

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 25
Total Number 29
Disease Relevance 4.59
Pain Relevance 6.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
neurons 8
plasma 4
juvenile 4
pituitary gland 4
secretory cells 2
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 226 100.00 Very High Very High Very High
Morphine 27 100.00 Very High Very High Very High
Enkephalin 26 100.00 Very High Very High Very High
antinociception 6 99.76 Very High Very High Very High
narcan 18 99.70 Very High Very High Very High
opiate 4 99.68 Very High Very High Very High
excitatory amino acid 4 99.66 Very High Very High Very High
Acupuncture 224 99.32 Very High Very High Very High
noradrenaline 7 99.18 Very High Very High Very High
tetrodotoxin 2 98.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 96 99.68 Very High Very High Very High
Precocious Puberty 172 98.66 Very High Very High Very High
Bordatella Infection 5 94.24 High High
Hyperalgesia 6 94.08 High High
Disease 30 93.12 High High
Polycystic Ovary Syndrome 253 92.20 High High
Endometriosis (extended) 6 89.80 High High
Galactorrhea 10 83.00 Quite High
Nociception 6 81.40 Quite High
Stress 246 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We revealed by immunocytochemistry that, regardless of age and sex, naloxone significantly increased the number of GnRH neurons expressing Fos, which was associated with increased LH secretion.
Positive_regulation (increased) of Gene_expression (expressing) of GnRH in neurons associated with narcan
1) Confidence 0.69 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20097261 Disease Relevance 0 Pain Relevance 0.22
Our findings demonstrate that DHT exposure increases both GnRH and AR expression in the MPO.
Positive_regulation (increases) of Gene_expression (expression) of GnRH associated with urological neuroanatomy
2) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.31 Pain Relevance 0
The injection of an LHRH antagonist, [D-Phe2,Pro3,D-Phe6] LHRH, to OVX rats in doses of 0.1, 1, or 10 ng/rat 30 min prior to morphine, enhanced and prolonged morphine-induced antinociception in a dose-dependent manner.
Positive_regulation (enhanced) of Gene_expression (injection) of LHRH associated with antinociception, antagonist and morphine
3) Confidence 0.50 Published 1990 Journal Endocrinology Section Abstract Doc Link 2197079 Disease Relevance 0.34 Pain Relevance 1.23
The injection of an LHRH antagonist, [D-Phe2,Pro3,D-Phe6] LHRH, to OVX rats in doses of 0.1, 1, or 10 ng/rat 30 min prior to morphine, enhanced and prolonged morphine-induced antinociception in a dose-dependent manner.
Positive_regulation (enhanced) of Gene_expression (injection) of LHRH associated with antinociception, antagonist and morphine
4) Confidence 0.50 Published 1990 Journal Endocrinology Section Abstract Doc Link 2197079 Disease Relevance 0.34 Pain Relevance 1.23
There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4.
Positive_regulation (increase) of Gene_expression (synthesis) of GnRH in juvenile associated with noradrenaline and excitatory amino acid
5) Confidence 0.50 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7648607 Disease Relevance 0 Pain Relevance 0.19
There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4.
Positive_regulation (participate) of Gene_expression (synthesis) of GnRH in juvenile associated with noradrenaline and excitatory amino acid
6) Confidence 0.50 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7648607 Disease Relevance 0 Pain Relevance 0.19
Three consecutive injections of LHRH produced significantly less LH release in PPL rats than in normal cycling female rats on diestrous day 2.
Positive_regulation (injections) of Gene_expression (injections) of LHRH
7) Confidence 0.50 Published 1976 Journal Endocrinology Section Abstract Doc Link 770158 Disease Relevance 0 Pain Relevance 0.09
In all 3 groups, the 2nd and 3rd injections of LHRH produced much greater increases in serum concentrations of LH than the 1st injection.
Positive_regulation (increases) of Gene_expression (produced) of LHRH
8) Confidence 0.50 Published 1976 Journal Endocrinology Section Abstract Doc Link 770158 Disease Relevance 0 Pain Relevance 0.10
The true precocious puberty model by neonatal administration of Danazol in female rats showed augmented expression of hypothalamic GnRH; the Nourishing "Yin"-Removing "Fire" Chinese Herb Mixture down-regulated the increased GnRH expression, and significantly delayed the sexual development of the precocious puberty rat.


Positive_regulation (augmented) of Gene_expression (expression) of GnRH associated with precocious puberty
9) Confidence 0.46 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.27 Pain Relevance 0.03
The true precocious puberty model by neonatal administration of Danazol in female rats showed augmented expression of hypothalamic GnRH; the Nourishing "Yin"-Removing "Fire" Chinese Herb Mixture down-regulated the increased GnRH expression, and significantly delayed the sexual development of the precocious puberty rat.



Positive_regulation (increased) of Gene_expression (expression) of GnRH associated with precocious puberty
10) Confidence 0.46 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1236957 Disease Relevance 0.43 Pain Relevance 0
The true precocious puberty model by neonatal administration of Danazol in female rats showed augmented expression of hypothalamic GnRH; the Nourishing "Yin"-Removing "Fire" Chinese Herb Mixture down-regulated the increased GnRH expression, and significantly delayed the sexual development of the precocious puberty rat.



Positive_regulation (augmented) of Gene_expression (expression) of GnRH associated with precocious puberty
11) Confidence 0.46 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1236957 Disease Relevance 0.44 Pain Relevance 0
The true precocious puberty model by neonatal administration of Danazol in female rats showed augmented expression of hypothalamic GnRH; the Nourishing "Yin"-Removing "Fire" Chinese Herb Mixture down-regulated the increased GnRH expression, and significantly delayed the sexual development of the precocious puberty rat.


Positive_regulation (increased) of Gene_expression (expression) of GnRH associated with precocious puberty
12) Confidence 0.46 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.26 Pain Relevance 0.03
GnRH (100 ng/ml), Ca2+ ionophore A23187 (2.5 microM), and the depolarizing agent ouabain (0.1-10 microM) all produced significant increases (P less than 0.05) in LH release; these effects were significantly reduced when the cells were preincubated with the organic Ca2+ channel blockers nifedipine (1-10 microM) and verapamil (1-10 microM) and with Co2+ (0.01-1 mM).
Positive_regulation (increases) of Gene_expression (produced) of GnRH
13) Confidence 0.45 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2845802 Disease Relevance 0 Pain Relevance 0.08
However, it is unclear whether androgens exert physiological or pathophysiological actions in females by activating AR expression in GnRH-expressing neurons [21].
Spec (whether) Positive_regulation (activating) of Gene_expression (expressing) of GnRH in neurons
14) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.52 Pain Relevance 0.03
However, it has been unclear whether androgens exert physiological or pathophysiological actions in females by activating AR expression in GnRH-expressing neurons [21].
Spec (whether) Positive_regulation (activating) of Gene_expression (expressing) of GnRH in neurons
15) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.21 Pain Relevance 0
Repeated low-frequency EA normalized estrous cyclicity and restored GnRH and AR protein expression.
Positive_regulation (restored) of Gene_expression (expression) of GnRH associated with acupuncture
16) Confidence 0.40 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2722078 Disease Relevance 0.41 Pain Relevance 0.27
Addition of tetrodotoxin (10(-6) M), to inhibit Na+-transduced electrical activity, also significantly enhanced LHRH migration.
Positive_regulation (enhanced) of Gene_expression (migration) of LHRH associated with tetrodotoxin
17) Confidence 0.39 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9502815 Disease Relevance 0 Pain Relevance 0.44
The discovery of the hypothalamic peptide, luteinising hormone releasing hormone (LHRH), and its stimulatory release of luteinising hormone (LH) from the pituitary gland led to the synthesis of LHRH analogues (i.e., hormone therapy).
Positive_regulation (led) of Gene_expression (synthesis) of LHRH in pituitary gland
18) Confidence 0.34 Published 2004 Journal Expert Opin Pharmacother Section Abstract Doc Link 14996640 Disease Relevance 0.39 Pain Relevance 0.11
The response of the anterior pituitary to exogenously administered LHRH in the morning (1000 h) and during the midafternoon hypersecretion of LH (1800 h) was markedly enhanced in animals exposed chronically to morphine.
Positive_regulation (enhanced) of Gene_expression (response) of LHRH in anterior pituitary associated with morphine
19) Confidence 0.32 Published 1987 Journal Endocrinology Section Abstract Doc Link 3032570 Disease Relevance 0 Pain Relevance 0.86
In previous studies, it was demonstrated that morphine pellet implantation markedly sensitized adult male rats to the subsequent elevations in serum luteinizing hormone (LH) levels produced by the opiate antagonist, naloxone.
Positive_regulation (elevations) of Gene_expression (produced) of serum luteinizing hormone associated with antagonist, narcan, opiate and morphine
20) Confidence 0.31 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3528453 Disease Relevance 0.07 Pain Relevance 0.71

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