INT350068

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0

endoplasmic reticulum (Hmox1, Ptgs2) enzyme binding (Hmox1, Ptgs2) oxidoreductase activity (Hmox1, Ptgs2) nucleus (Hmox1, Ptgs2) protein complex (Ptgs2) cytoplasm (Ptgs2)

Anatomy Link Frequency brain 3 Hmox1 (Mus musculus) Ptgs2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 21 5.00 cytokine 3 5.00 COX-2 inhibitor 2 5.00 Inflammatory response 2 5.00 Inflammatory mediators 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Bacterial Infection 6 91.16 Infection 3 66.84 INFLAMMATION 19 5.00 Stress 7 5.00 Injury 6 5.00 Vasculitis 4 5.00 Apoptosis 2 5.00 Sepsis 2 5.00 Pain 1 5.00 Adenovirus Infection 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells Background

Positive_regulation (Induction) of heme oxygenase-1 in brain Negative_regulation (attenuates) of Gene_expression (expression) of cyclooxygenase-2 in brain

1) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Title Doc Link PMC3002338 Disease Relevance 0.16 Pain Relevance 0

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