INT350076

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.29
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Hmox1, Ptger2) signal transduction (Hmox1, Ptger2) endoplasmic reticulum (Hmox1)
enzyme binding (Hmox1) cytosol (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
endothelial cells 3
Hmox1 (Mus musculus)
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 63 95.44 Very High Very High Very High
Pain 3 88.56 High High
Inflammatory response 6 86.20 High High
cytokine 9 76.56 Quite High
Inflammatory mediators 3 69.04 Quite High
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 57 95.44 Very High Very High Very High
Vasculitis 12 91.84 High High
Bacterial Infection 18 89.04 High High
Pain 3 88.56 High High
Injury 18 83.28 Quite High
Stress 21 56.48 Quite High
Brain Injury 3 41.24 Quite Low
Encephalitis 3 34.40 Quite Low
Apoptosis 6 23.36 Low Low
Sepsis 6 9.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate that LPS-induced COX-2 expression and PGE2 production is inhibited by induction of HO-1.
Positive_regulation (induction) of HO-1 Negative_regulation (inhibited) of Gene_expression (production) of PGE2
1) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.34 Pain Relevance 0.04
In the present study, our results are the first report to show that induction of HO-1 attenuates LPS-induced COX-2 expression and PGE2 synthesis in endothelial cells.
Positive_regulation (induction) of HO-1 in endothelial cells Negative_regulation (attenuates) of Gene_expression (synthesis) of PGE2 in endothelial cells
2) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.60 Pain Relevance 0.24
In the present study, LPS-induced COX-2 expression and PGE2 synthesis was inhibited by HO-1 induction by pretreatment with either CoPP or Adv-HO-1 in murine bEnd.3 cells.
Positive_regulation (induction) of HO-1 Negative_regulation (inhibited) of Gene_expression (synthesis) of PGE2
3) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.35 Pain Relevance 0.22

General Comments

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