INT350081

Context Info Confidence 0.07 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.20 Pain Relevance 0.15

cytosol (Pik3r1, Hmox1) signal transduction (Pik3r1, Hmox1) nucleus (Pik3r1, Hmox1) endoplasmic reticulum (Hmox1) intracellular (Pik3r1) enzyme binding (Hmox1)

Pik3r1 (Mus musculus) Hmox1 (Mus musculus)

Pain Link Frequency Relevance Heat COX-2 inhibitor 2 95.68 Inflammation 21 63.96 cytokine 3 46.80 Inflammatory response 2 5.00 Inflammatory mediators 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Stress 7 84.48 INFLAMMATION 19 63.96 Bacterial Infection 6 5.00 Injury 6 5.00 Vasculitis 4 5.00 Infection 3 5.00 Apoptosis 2 5.00 Sepsis 2 5.00 Pain 1 5.00 Adenovirus Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, it has been also reported that the COX-2 metabolite, PGE2, induces HO-1 through PKA and PI3K signaling pathways via EP2 receptors in C6 cells [50].

PI3K Positive_regulation (induces) of HO-1

1) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.20 Pain Relevance 0.15

General Comments

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