INT35009

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Context Info
Confidence 0.41
First Reported 1987
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 10.74
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CSAD) small molecule metabolic process (CSAD) lyase activity (CSAD)
cellular nitrogen compound metabolic process (CSAD)
Anatomy Link Frequency
neuronal 1
blood vessels 1
puncture 1
CSAD (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 79 100.00 Very High Very High Very High
imagery 7 99.74 Very High Very High Very High
excitatory amino acid 1 97.68 Very High Very High Very High
Migraine 14 97.32 Very High Very High Very High
Pain 3 93.16 High High
Inflammation 7 92.68 High High
backache 1 85.96 High High
tolerance 2 81.76 Quite High
Arthritis 2 75.00 Quite High
cerebral cortex 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Depression 79 100.00 Very High Very High Very High
Disease 17 100.00 Very High Very High Very High
Cat Scratch Fever 12 100.00 Very High Very High Very High
Communicable Diseases 2 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 4 99.76 Very High Very High Very High
Hypoxia 52 99.24 Very High Very High Very High
Pressure And Volume Under Development 10 98.40 Very High Very High Very High
Congenital Anomalies 1 98.28 Very High Very High Very High
Stroke 6 98.16 Very High Very High Very High
Convulsion 4 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prevalent view that CSD is intimately associated with vasodilatation was accordingly not supported.
CSD Binding (associated) of associated with depression and increased venous pressure under development
1) Confidence 0.41 Published 1987 Journal Acta Neurol. Scand. Section Abstract Doc Link 3107334 Disease Relevance 0.86 Pain Relevance 0.39
Therefore studying the mechanisms that underlie CSD, such as ion channel manipulation, and observing rCBF changes may help our understanding of migraine aura.
CSD Binding (underlie) of associated with epilepsy, depression and migraine
2) Confidence 0.32 Published 2008 Journal Brain Res. Section Abstract Doc Link 18656463 Disease Relevance 0.98 Pain Relevance 0.49
Only a few cases of rheumatic manifestations associated with CSD have been described in the literature.
CSD Binding (associated) of associated with cat scratch fever
3) Confidence 0.31 Published 1998 Journal Z Rheumatol Section Abstract Doc Link 9702836 Disease Relevance 1.36 Pain Relevance 0.18
Cat scratch disease (CSD) is a rarely recognized infectious disease in Germany.
CSD Binding (recognized) of associated with cat scratch fever and communicable diseases
4) Confidence 0.31 Published 1998 Journal Z Rheumatol Section Abstract Doc Link 9702836 Disease Relevance 1.02 Pain Relevance 0.13
Eleven other cases of this unusual manifestation associated with CSD have been reported in the literature and are reviewed.
CSD Binding (associated) of associated with disease
5) Confidence 0.31 Published 1999 Journal Clin. Infect. Dis. Section Abstract Doc Link 10064243 Disease Relevance 0.92 Pain Relevance 0.13
These data demonstrate that increased formation of endogenous NO associated with CSD is critical for subsequent, rapid recovery of cellular ionic homeostasis.
CSD Neg (NO) Binding (associated) of associated with depression
6) Confidence 0.23 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726826 Disease Relevance 0.76 Pain Relevance 0.41
In this case, the molecular targets for NO may be located either on brain cells to suppress mechanisms directly involved in CSD genesis, or on local blood vessels to couple flow to the increased energy demand associated with CSD.
CSD Binding (associated) of in blood vessels associated with depression
7) Confidence 0.23 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726826 Disease Relevance 0.63 Pain Relevance 0.29
These were larger in amplitude ( approximately 20%), longer lasting and more delayed in onset (13-33 min) than the brief propagating (90 s) BOLD increase ( approximately 4%) already known to be associated with CSD on earlier occasions.
CSD Binding (associated) of associated with depression
8) Confidence 0.17 Published 2003 Journal Magn Reson Imaging Section Abstract Doc Link 14684218 Disease Relevance 0.40 Pain Relevance 0.31
This novel experimental strategy was validated by imaging the changes associated with CSD elicited by application of high K(+) medium on the cortical surface.
CSD Binding (associated) of associated with imagery
9) Confidence 0.10 Published 2009 Journal Neuroimage Section Abstract Doc Link 19100842 Disease Relevance 0.39 Pain Relevance 0.36
In mammalian tissue CSD has been associated with several important pathologies including stroke, seizures and migraine [4]–[6].
CSD Binding (associated) of associated with convulsion, depression, stroke and migraine
10) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137934 Disease Relevance 1.04 Pain Relevance 0.43
Another association is with the CSD[12] observed in young, otherwise healthy individuals with fever, malaise, lymphadenopathy and a history of exposure to or puncture wounds by cats, with neuroretinitis as a characteristic clinical feature, caused by the organism Bartonella henselae.
CSD Binding (association) of in puncture associated with retinitis, lymphadenopathy, injury, fever and disease
11) Confidence 0.04 Published 2008 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2771962 Disease Relevance 1.80 Pain Relevance 0.03
In contrast to the insect system, CSD in mammals is associated with local tissue hypoxia and neuronal swelling due to energy consumption that is not met with adequate oxygen supply [28].
CSD Binding (associated) of in neuronal associated with pressure and volume under development, depression and hypoxia
12) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137934 Disease Relevance 0.59 Pain Relevance 0.05

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