INT350098

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

endoplasmic reticulum (PSEN2, Hmox1) cytosol (PSEN2, Hmox1) cell death (PSEN2, Hmox1) Golgi apparatus (PSEN2) enzyme binding (Hmox1) embryo development (PSEN2)

PSEN2 (Homo sapiens) Hmox1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 21 32.24 cytokine 3 5.00 COX-2 inhibitor 2 5.00 Inflammatory response 2 5.00 Inflammatory mediators 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Stress 7 32.96 INFLAMMATION 19 32.24 Bacterial Infection 6 5.00 Injury 6 5.00 Vasculitis 4 5.00 Infection 3 5.00 Apoptosis 2 5.00 Sepsis 2 5.00 Pain 1 5.00 Adenovirus Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As shown in Figure 4B, transfection with adv-HO-1 (Adv, MOI = 10, 48 h) enhanced HO-1 expression and attenuated LPS-induced COX-2 expression.

Gene_expression (transfection) of Adv Positive_regulation (enhanced) of Gene_expression (expression) of HO-1

1) Confidence 0.39 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0

General Comments

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