INT350125

Context Info Confidence 0.41 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0.10

Anatomy Link Frequency keratinocytes 2 Ifna (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 98.04 tolerance 2 5.00 Potency 2 5.00 corticosteroid 1 5.00 methotrexate 1 5.00 cryotherapy 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Cancer 3 94.48 Necrosis 1 94.00 Hypersensitivity 2 80.68 Alopecia Areata 31 75.48 Contact Dermatitis 6 37.36 Alopecia 5 36.28 Disease 5 5.00 Eczema 4 5.00 Non-genital Cutaneous Warts 3 5.00 Recurrence 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A‘cytokine inhibitor’ theory has been planned, which proposes a possible interference of contact allergens with the pre-existing proinflammatory cytokines and also their continued production by follicular keratinocytes.[2] The other events noted are a decrease in the raised interferon ?

Negative_regulation (decrease) of Gene_expression (raised) of interferon in keratinocytes associated with cytokine

1) Confidence 0.41 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002409 Disease Relevance 0.49 Pain Relevance 0.10

General Comments

This test has worked.