INT35018

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 1987
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
nerve 2
cerebral cortex 2
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 98.00 Very High Very High Very High
cerebral cortex 6 97.72 Very High Very High Very High
tetrodotoxin 3 90.52 High High
Disease Link Frequency Relevance Heat
Convulsion 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The calmodulin antagonists N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7, strongly) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5, weakly) reduced the PTZ-stimulatory effect on synapsin I phosphorylation by about 75 and 15%, respectively, whereas these antagonists had essentially no effect on PTZ-stimulated synaptosomal accumulation of Ca2+.
Regulation (effect) of Phosphorylation (phosphorylation) of synapsin I associated with antagonist
1) Confidence 0.44 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.26
To determine precisely how pentylenetetrazole (PTZ) is involved in the biochemical processes at the presynaptic nerve terminal, the effect of PTZ, under various conditions, on the phosphorylation of synapsin I (previously called protein I) was investigated, using 32Pi in synaptosomes from rat cerebral cortex.
Spec (investigated) Regulation (effect) of Phosphorylation (phosphorylation) of synapsin I in nerve associated with cerebral cortex
2) Confidence 0.44 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.09
Involvement of pentylenetetrazole in synapsin I phosphorylation associated with calcium influx in synaptosomes from rat cerebral cortex.
Regulation (Involvement) of Phosphorylation (phosphorylation) of synapsin I in cerebral cortex associated with cerebral cortex
3) Confidence 0.26 Published 1987 Journal Biochem. Pharmacol. Section Title Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.18

General Comments

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