INT35019

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Context Info
Confidence 0.82
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.33
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
nerve 2
neurons 1
cerebral cortex 1
forebrain 1
external 1
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fortral 3 100.00 Very High Very High Very High
agonist 12 99.62 Very High Very High Very High
Neurotransmitter 2 99.60 Very High Very High Very High
opiate 16 99.46 Very High Very High Very High
Glutamate 11 99.36 Very High Very High Very High
antagonist 19 98.00 Very High Very High Very High
cerebral cortex 12 97.72 Very High Very High Very High
tetrodotoxin 7 97.36 Very High Very High Very High
Morphine 5 95.88 Very High Very High Very High
Spinal cord 4 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 7 96.88 Very High Very High Very High
Ganglion Cysts 2 94.08 High High
Opiate Addiction 1 65.76 Quite High
Depression 44 23.16 Low Low
Death 9 10.16 Low Low
Apoptosis 13 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 8 5.00 Very Low Very Low Very Low
Kernicterus 7 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since opiates were shown to attenuate neurotransmitter release and reduce synapsin I phosphorylation, it is suggested that the increase in synapsin I levels would lead to the requirement of higher amounts of opiate agonists to obtain the opiate physiological effects.
Phosphorylation (phosphorylation) of synapsin I associated with neurotransmitter, agonist and opiate
1) Confidence 0.82 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.07 Pain Relevance 1.41
We have previously shown that acute kappa-opiate agonist treatment reduces phosphorylation of synapsin I stimulated by depolarizing agents (such as 60 mM KCl).
Phosphorylation (phosphorylation) of synapsin I associated with agonist and opiate
2) Confidence 0.82 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8436965 Disease Relevance 0.17 Pain Relevance 1.04
To determine precisely how pentylenetetrazole (PTZ) is involved in the biochemical processes at the presynaptic nerve terminal, the effect of PTZ, under various conditions, on the phosphorylation of synapsin I (previously called protein I) was investigated, using 32Pi in synaptosomes from rat cerebral cortex.
Phosphorylation (phosphorylation) of synapsin I in nerve associated with cerebral cortex
3) Confidence 0.80 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.09
Involvement of pentylenetetrazole in synapsin I phosphorylation associated with calcium influx in synaptosomes from rat cerebral cortex.
Phosphorylation (phosphorylation) of synapsin I in cerebral cortex associated with cerebral cortex
4) Confidence 0.80 Published 1987 Journal Biochem. Pharmacol. Section Title Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.18
The calmodulin antagonists N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7, strongly) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5, weakly) reduced the PTZ-stimulatory effect on synapsin I phosphorylation by about 75 and 15%, respectively, whereas these antagonists had essentially no effect on PTZ-stimulated synaptosomal accumulation of Ca2+.
Phosphorylation (phosphorylation) of synapsin I associated with antagonist
5) Confidence 0.80 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.26
Moreover, the PTZ-stimulated synapsin I phosphorylation was reversed by addition of EGTA sufficient to chelate all external free Ca2+.
Phosphorylation (phosphorylation) of synapsin I in external
6) Confidence 0.80 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.22
The PTZ-stimulatory effects of both synapsin I phosphorylation and synaptosomal accumulation of Ca2+ were inhibited markedly by tetrodotoxin as well as by cobalt chloride and lanthanum chloride.
Phosphorylation (phosphorylation) of synapsin I associated with tetrodotoxin
7) Confidence 0.80 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.25
Phosphorylation of synapsin I and dynamin in rat forebrain synaptosomes: modulation by sigma (sigma) ligands.
Phosphorylation (Phosphorylation) of synapsin I in forebrain associated with fortral
8) Confidence 0.73 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 7659295 Disease Relevance 0 Pain Relevance 0.27
These results suggest that PTZ causes the influx of Ca2+ into the presynaptic nerve terminal secondary to the elevated Na+ and is consequently involved in the synapsin I phosphorylation step, facilitating the Ca2+/calmodulin-mediated presynaptic event leading to seizure discharge.
Phosphorylation (phosphorylation) of synapsin I in nerve associated with convulsion
9) Confidence 0.61 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0.10 Pain Relevance 0.23
Following calcium-related events, several of these receptors, such as P2Y1, P2X3 and P2X7, were also shown to induce CaMKII and synapsin I phosphorylation and subsequent glutamate release in rat granule neurons [8].
Phosphorylation (phosphorylation) of synapsin I in neurons associated with glutamate
10) Confidence 0.18 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.05
Regarding possible mechanisms by which UCB inhibits glutamate release, one possibility may involve the inhibition of synapsin I phosphorylation [43], which plays an important role in neurotransmitter release process [44].
Phosphorylation (phosphorylation) of synapsin I associated with neurotransmitter and glutamate
11) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0.28

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