INT350216

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
internal 2
ITPR3 (Homo sapiens)
TNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 10 96.28 Very High Very High Very High
Inflammation 5 83.12 Quite High
Potency 1 38.68 Quite Low
Glutamate 1 29.68 Quite Low
chemokine 1 29.04 Quite Low
Cannabinoid 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 83.12 Quite High
Disease 1 21.68 Low Low
Pain 4 5.00 Very Low Very Low Very Low
Cough 1 5.00 Very Low Very Low Very Low
Burns 1 5.00 Very Low Very Low Very Low
Pharyngitis 1 5.00 Very Low Very Low Very Low
Toothache 1 5.00 Very Low Very Low Very Low
Acute Monocytic Leukemia 1 5.00 Very Low Very Low Very Low
Snake Bites 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The participation of the IP3 receptor in the Echinacea-induced calcium release is suggested by treatment of HEK293 cells with the specific membrane-permeable IP3 receptor antagonist, 2-APB [17]. 2-APB is able to completely abolish the Echinacea-induced calcium release from internal stores. 2-APB has been reported to enhance leakage of Ca2+ from the ER and inhibit SERCA activity, resulting in enhancement of Ca2+ signaling [27].
IP3 receptor Regulation (participation) of Localization (release) of Echinacea-induced in internal associated with antagonist
1) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.08 Pain Relevance 0.09

General Comments

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