INT350257

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pnlip) extracellular region (Pnlip) lipid metabolic process (Pnlip)
Anatomy Link Frequency
fat 1
3T3-L1 1
Slc12a6 (Rattus norvegicus)
Pnlip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 9 57.96 Quite High
metalloproteinase 9 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 6 96.20 Very High Very High Very High
Obesity 150 95.44 Very High Very High Very High
Disorder Of Lipid Metabolism 18 80.64 Quite High
Body Weight 18 68.76 Quite High
Hypertrophy 12 66.48 Quite High
Diabetes Mellitus 12 62.00 Quite High
Hypertension 6 58.72 Quite High
Impaired Glucose Tolerance 9 57.96 Quite High
Cancer 9 57.36 Quite High
Hyperplasia 6 28.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of KCL suppressed pancreatic lipase activity in a dose-dependent manner up to a concentration of 1 mg/mL, but this effect was not seen when acetic acid was added.

3T3-L1 preadipocyte differentiation and aP2 and PPAR?

KCL Negative_regulation (suppressed) of pancreatic lipase in 3T3-L1
1) Confidence 0.03 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.41 Pain Relevance 0
Our data showed that KCL inhibited pancreatic lipase activity in a dose-dependent manner in vitro.
KCL Negative_regulation (inhibited) of pancreatic lipase
2) Confidence 0.03 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.57 Pain Relevance 0.03
Furthermore, KCL significantly inhibited pancreatic lipase activity in vitro, and also significantly inhibited fat accumulation and mRNA expression of fatty acid binding protein 2 (aP2) and peroxisome proliferator-activated ?
KCL Negative_regulation (inhibited) of pancreatic lipase in fat
3) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC3002919 Disease Relevance 0.56 Pain Relevance 0

General Comments

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