INT35027

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Context Info
Confidence 0.02
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 6
Total Number 6
Disease Relevance 4.26
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mononuclear cells 2
blood 1
synovial fluid 1
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 12 97.56 Very High Very High Very High
spinal inflammation 8 96.64 Very High Very High Very High
Pain 43 96.48 Very High Very High Very High
Central nervous system 28 92.84 High High
Inflammation 38 88.88 High High
Arthritis 1 84.96 Quite High
cytokine 28 84.08 Quite High
cINOD 5 72.72 Quite High
Sciatic nerve 4 60.68 Quite High
Analgesic 2 59.72 Quite High
Disease Link Frequency Relevance Heat
Infection 26 99.12 Very High Very High Very High
Mantle-cell Lymphoma 26 98.16 Very High Very High Very High
Rheumatoid Arthritis 12 97.56 Very High Very High Very High
Low Back Pain 8 96.64 Very High Very High Very High
Pain 32 94.64 High High
Immunization 1 94.64 High High
Disease 8 93.68 High High
INFLAMMATION 45 88.88 High High
Arthritis 1 84.96 Quite High
Sepsis 2 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CFA is an immune response enhancer, effective in stimulating cell-mediated immunity and may lead to increase of the production of certain immunoglobulin in the absence of an infection.
Positive_regulation (increase) of Gene_expression (production) of immunoglobulin associated with infection
1) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992508 Disease Relevance 1.34 Pain Relevance 0.79
The cells express relatively intense surface immunoglobulin M (IgM) and/or immunoglobulin D (IgD) and are usually positive for CD5, FMC7 and CD43, but negative for CD10 and BCL6.
Positive_regulation (positive) of Gene_expression (express) of immunoglobulin
2) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2853553 Disease Relevance 1.39 Pain Relevance 0
Furthermore, chronic treatment with nefopam potentiated significantly the production of total immunoglobulin induced by heat killed E. coli.
Positive_regulation (induced) of Gene_expression (production) of immunoglobulin
3) Confidence 0.00 Published 2007 Journal Int. Immunopharmacol. Section Abstract Doc Link 17178394 Disease Relevance 0.15 Pain Relevance 0.28
Spontaneous and pokeweed mitogen induced in vitro immunoglobulin and IgM rheumatoid factor production by peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis.
Positive_regulation (induced) of in blood Gene_expression (production) of immunoglobulin in mononuclear cells associated with rheumatoid arthritis
4) Confidence 0.00 Published 1983 Journal J. Rheumatol. Section Title Doc Link 6887161 Disease Relevance 0.51 Pain Relevance 0.40
Elevated serum interleukin-2 receptor; increased in vitro immunoglobulin synthesis and lack of response to testosterone-enhanced in vitro interleukin-2 production in ankylosing spondylitis.
Positive_regulation (increased) of Gene_expression (synthesis) of immunoglobulin associated with spinal inflammation
5) Confidence 0.00 Published 1987 Journal Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi Section Title Doc Link 3109849 Disease Relevance 0.36 Pain Relevance 0.36
Spontaneous and pokeweed mitogen induced in vitro immunoglobulin and IgM rheumatoid factor production by peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis.
Positive_regulation (induced) of in synovial fluid Gene_expression (production) of immunoglobulin in mononuclear cells associated with rheumatoid arthritis
6) Confidence 0.00 Published 1983 Journal J. Rheumatol. Section Title Doc Link 6887161 Disease Relevance 0.51 Pain Relevance 0.40

General Comments

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