INT35028

Context Info Confidence 0.47 First Reported 1987 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 14 Total Number 14 Disease Relevance 10.05 Pain Relevance 4.36

signal transduction (IL2RG) plasma membrane (IL2RG)

Anatomy Link Frequency bowel 2 femur 2 plasma 1 Neuron 1 IL2RG (Homo sapiens)

Pain Link Frequency Relevance Heat Crohn's disease 32 99.90 spinal inflammation 8 99.76 medulla 1 99.20 Inflammation 33 98.88 anesthesia 13 98.16 rheumatoid arthritis 5 97.56 cytokine 81 95.68 neuralgia 3 95.44 abdominal pain 13 91.88 isoflurane 1 88.64

Disease Link Frequency Relevance Heat Disease 100 99.90 Lymphatic System Cancer 3 99.80 Low Back Pain 8 99.76 Necrosis 3 99.62 Cancer 23 99.44 Chronic Hepatitis 47 99.28 Inflammatory Bowel Disease 24 98.88 Systemic Lupus Erythematosus 2 98.76 Rheumatoid Arthritis 5 97.56 Hypercalcemia 22 97.12

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Soluble IL-2 receptor was elevated and malignant lymphoma was clinically diagnosed.

Positive_regulation (elevated) of IL-2 receptor associated with lymphatic system cancer

1) Confidence 0.47 Published 2009 Journal Rinsho Ketsueki Section Abstract Doc Link 19265306 Disease Relevance 0.61 Pain Relevance 0.22

Levels of interleukin-2 receptors (IL-2R), as measured by a double-antibody "sandwich" enzyme-linked immunosorbent assay technique, were markedly elevated in the serum of patients with systemic lupus erythematosus, rheumatoid arthritis, and bacterial endocarditis, but not in patients with acute gout.

Positive_regulation (elevated) of IL-2R associated with bacterial endocarditis, rheumatoid arthritis, crystal associated disease and systemic lupus erythematosus

2) Confidence 0.42 Published 1988 Journal Arthritis Rheum. Section Abstract Doc Link 3263865 Disease Relevance 0.76 Pain Relevance 0.09

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Positive_regulation (soluble) of soluble interleukin-2 receptor associated with necrosis, anesthesia and cancer

3) Confidence 0.28 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.36 Pain Relevance 0.52

Upregulation of IFN-gamma and soluble interleukin-2 receptor release and altered serum cortisol and prolactin concentration during general anesthesia.

Positive_regulation (Upregulation) of soluble interleukin-2 receptor associated with anesthesia

4) Confidence 0.17 Published 2001 Journal J. Interferon Cytokine Res. Section Title Doc Link 11710990 Disease Relevance 0.23 Pain Relevance 0.71

Serum tumor markers such as sIL-2R (soluble interleukin-2 receptor) and TK (thymidine kinase) were elevated to 2870 U/ml and 15 U/L, respectively, but CEA (Carcinoembryonic Antigen), CA 19-9 (Carbohydrate Antigen 19-9) and NSE (Neuron-specific enolase) were normal.

Positive_regulation (elevated) of interleukin-2 receptor in Neuron associated with cancer

5) Confidence 0.12 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2615780 Disease Relevance 0.93 Pain Relevance 0.19

Levamisole also could induce an increase in the level of interleukin 2 receptor [31] and T helper to T suppressor ratio in many dermatologic disorders [32].

Positive_regulation (increase) of interleukin 2 receptor

6) Confidence 0.07 Published 2006 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1540413 Disease Relevance 0 Pain Relevance 0

Patients with moderate/severe Crohn's disease had elevated mean serum levels of IL-6 and IL-2R when compared with those with mild and inactive disease (p < 0.05); however, neither marker distinguished between inactive and mild disease.

Positive_regulation (elevated) of IL-2R associated with crohn's disease and disease

7) Confidence 0.07 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.80 Pain Relevance 0.60

Elevation of serum interleukin-6 but not serum-soluble interleukin-2 receptor in children with Crohn's disease.

Positive_regulation (Elevation) of interleukin-2 receptor associated with crohn's disease and disease

8) Confidence 0.07 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Title Doc Link 8856584 Disease Relevance 1.50 Pain Relevance 0.46

Previous studies have demonstrated elevated serum levels of interleukin-6 (IL-6) and the soluble interleukin-2 receptor (IL-2R, CD25) in individuals with inflammatory bowel disease (IBD).

Positive_regulation (elevated) of interleukin-2 receptor in bowel associated with inflammatory bowel disease and inflammation

9) Confidence 0.04 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.05 Pain Relevance 0.25

Previous studies have demonstrated elevated serum levels of interleukin-6 (IL-6) and the soluble interleukin-2 receptor (IL-2R, CD25) in individuals with inflammatory bowel disease (IBD).

Positive_regulation (elevated) of IL-2R in bowel associated with inflammatory bowel disease and inflammation

10) Confidence 0.04 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.05 Pain Relevance 0.26

The results showed: In vitro synthesis of IgG, IgA and IgM was significantly higher in AS than in controls; In vitro synthesis of IL-2 was significantly enhanced by testosterone in normal control, but not in AS; and Serum IL-2R was significantly elevated in patients with AS.

Positive_regulation (elevated) of IL-2R associated with spinal inflammation

11) Confidence 0.01 Published 1987 Journal Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi Section Abstract Doc Link 3109849 Disease Relevance 0.52 Pain Relevance 0.55

The plasma concentrations of IL-2R and IL-5 were found to be increased in all patients.

Positive_regulation (increased) of IL-2R in plasma

12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.24 Pain Relevance 0.40

In conclusion, our study suggest that BMD of femur, serum IL-2r, IL-6, IL-8, PTH, and CTX levels were higher in children with chronic hepatitis B treated with IFN-alpha alone or combination with lamivudine than in healthy children.

Positive_regulation (higher) of IL-2r in femur associated with chronic hepatitis

13) Confidence 0.01 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1242225 Disease Relevance 0.51 Pain Relevance 0.04

In conclusion, our study suggest that BMD of femur, serum IL-2r, IL-6, IL-8, PTH, and CTX levels were higher in children with chronic hepatitis B treated with IFN-alpha alone or combination with lamivudine than in healthy children.

Positive_regulation (higher) of IL-2r in femur associated with chronic hepatitis

14) Confidence 0.01 Published 2005 Journal BMC Gastroenterol Section Abstract Doc Link PMC1242225 Disease Relevance 0.47 Pain Relevance 0.07

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