INT35029

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Context Info
Confidence 0.43
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 66
Total Number 66
Disease Relevance 26.37
Pain Relevance 13.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 20
microglia 10
satellite cells 6
macrophages 4
fibroblasts 4
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 314 100.00 Very High Very High Very High
COX2 157 100.00 Very High Very High Very High
Hyperalgesia 37 100.00 Very High Very High Very High
Serotonin 7 99.80 Very High Very High Very High
Inflammation 967 99.76 Very High Very High Very High
agonist 150 99.70 Very High Very High Very High
Inflammatory stimuli 60 98.96 Very High Very High Very High
cytokine 207 98.60 Very High Very High Very High
Eae 34 97.28 Very High Very High Very High
anesthesia 27 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1423 100.00 Very High Very High Very High
Hyperalgesia 52 100.00 Very High Very High Very High
Stress 120 99.72 Very High Very High Very High
Head & Neck Cancer 48 99.36 Very High Very High Very High
Malignant Neoplastic Disease 16 99.16 Very High Very High Very High
Breast Cancer 4 98.92 Very High Very High Very High
Cancer 299 98.84 Very High Very High Very High
Metastasis 25 98.52 Very High Very High Very High
Ulcers 9 98.44 Very High Very High Very High
Fever 242 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-adrenergic agonist isoproterenol increases COX-2 protein and PGE2 synthesis in microglial cells [8].
Positive_regulation (increases) of Gene_expression (synthesis) of PGE2 in microglial cells associated with agonist
1) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.31 Pain Relevance 0.25
Myometrial activity at parturition may change from an active quiescent to an active contractile state in concert with a decline in expression of the relaxatory EP2 receptors and up-regulation of contractile FP receptors.
Positive_regulation (up-regulation) of Gene_expression (expression) of EP2
2) Confidence 0.41 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746738 Disease Relevance 0 Pain Relevance 0
Increased PGE2 levels may in addition stimulate the microglial EP2 receptor, which is linked to cAMP formation [74] and thereby contribute to the inactivation of microglia.
Positive_regulation (Increased) of Gene_expression (levels) of PGE2 in microglia
3) Confidence 0.31 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.28 Pain Relevance 0.31
In addition, forskolin occluded the enhancement produced by PGE2.
Positive_regulation (enhancement) of Gene_expression (produced) of PGE2 in PGE2
4) Confidence 0.31 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2063498 Disease Relevance 0.37 Pain Relevance 0.22
Norepinephrine strongly enhanced COX-2 expression and PGE2 production induced by lipopolysaccharide (LPS).
Positive_regulation (enhanced) of Gene_expression (production) of PGE2
5) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2819253 Disease Relevance 0.14 Pain Relevance 0.32
The ex vivo rate of basal or bacterial endotoxin-induced synthesis of PGE2 by different brain regions, including the preoptic area was not affected by HU-210 administration.
Positive_regulation (induced) of Gene_expression (synthesis) of PGE2 in brain
6) Confidence 0.24 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7617143 Disease Relevance 0.27 Pain Relevance 0.48
Likewise, in the present study, the lack of IL-6 release was associated with higher PGE2 production by AM incubated with smaller 0.5 ?
Positive_regulation (higher) of Gene_expression (production) of PGE2
7) Confidence 0.19 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.34 Pain Relevance 0.17
This suppressive effect of soluble ferric citrate on PGE2 in fibroblasts [34] contrasts our findings that more soluble iron enhances PGE2 synthesis in AM.
Positive_regulation (enhances) of Gene_expression (synthesis) of PGE2 in fibroblasts
8) Confidence 0.19 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.26 Pain Relevance 0.09
In case of AM treated with carbonyl iron particles, PGE2 production was increased [22] as observed in the present study.
Positive_regulation (increased) of Gene_expression (production) of PGE2
9) Confidence 0.19 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.21 Pain Relevance 0.08
We have recently shown in in vitro studies that ultrafine particles induce PGE2 production and this effect is modulated by particle size, specific surface area and composition [8,9].
Positive_regulation (induce) of Gene_expression (production) of PGE2
10) Confidence 0.19 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.40 Pain Relevance 0.20
These data reveal that the suppressive effect of the small particles on IL-6 release (Figure 3A) was caused by an enhanced PGE2 synthesis (Figure 3B) compared to the large particles.


Positive_regulation (enhanced) of Gene_expression (synthesis) of PGE2
11) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.45 Pain Relevance 0.11
Due to this observation we suggest that soluble iron arising from dissolved iron particles within AM modulates particle-induced IL-6 production via PGE2.
Positive_regulation (induced) of Gene_expression (production) of PGE2
12) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.57 Pain Relevance 0.32
m Fe2O3 particles caused a substantial IL-6 release from AM (Figure 3A), cellular PGE2 production was much greater with the small 0.5 ?
Positive_regulation (cellular) of Gene_expression (production) of PGE2
13) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.46 Pain Relevance 0.31
m particles, it can be concluded that the inflammatory response of small Fe2O3 particles was inhibited due to higher PGE2 production caused by higher levels of soluble iron within AM.
Positive_regulation (caused) of Gene_expression (production) of PGE2 associated with inflammatory response
14) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.34 Pain Relevance 0.20
Figure 3B shows that in the absence of indomethacin the intracellular PGE2 synthesis is enhanced by the large (1.9-fold; *P < 0.05) and even more by the small particles (2.5-fold; **P < 0.005) compared to non-particle baseline.
Positive_regulation (enhanced) of Gene_expression (synthesis) of PGE2
15) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.12 Pain Relevance 0.06
Likewise, in the present study, the lack of IL-6 release was associated with higher PGE2 production by AM incubated with smaller 0.5 ?
Positive_regulation (higher) of Gene_expression (production) of PGE2
16) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.34 Pain Relevance 0.17
Furthermore, there is evidence for a relationship between IL-6 and PGE2 production, since exposure of NO2 to rats decreased the levels of TNF- and IL-6 in BAL fluids, whereas PGE2 production was increased [35].
Positive_regulation (increased) of Gene_expression (production) of PGE2
17) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.42 Pain Relevance 0.21
Our data supports the hypothesis that soluble iron within AM modulates particle-core induced inflammatory responses via increased PGE2 synthesis and inhibiting IL-6 release.
Positive_regulation (increased) of Gene_expression (synthesis) of PGE2 associated with inflammatory response
18) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.43 Pain Relevance 0.22
Our data supports the hypothesis that soluble iron within AM modulates particle-core induced inflammatory responses via increased PGE2 synthesis and inhibiting IL-6 release.
Positive_regulation (induced) of Gene_expression (synthesis) of PGE2 associated with inflammatory response
19) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.44 Pain Relevance 0.22
The early activation of PGE2 synthesis involves phosphorylation of cPLA2 (lung) and transcriptional up-regulation of COX-2 (lung and liver).
Positive_regulation (activation) of Gene_expression (synthesis) of PGE2 in lung
20) Confidence 0.13 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.63 Pain Relevance 0.09

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