INT350374

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
sensory neurons 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 12 98.68 Very High Very High Very High
qutenza 29 89.56 High High
Cannabinoid receptor 2 86.44 High High
Neuropathic pain 1 51.44 Quite High
Nerve growth factor 5 5.00 Very Low Very Low Very Low
Lasting pain 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
nociceptor 3 5.00 Very Low Very Low Very Low
induced neuropathy 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 10 85.92 High High
Neuropathic Pain 7 51.44 Quite High
Leukemia 1 21.00 Low Low
Pain 7 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Hypesthesia 2 5.00 Very Low Very Low Very Low
Non-diabetic Peripheral Neuropathy 2 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CB2 receptors are G protein coupled receptors expressed by DRG neurons, and CB2 agonists have been shown to inhibit adenylyl cyclase, and reduce cAMP, to inhibit TRPV1 sensitization in human sensory neurons in vitro [64].
Negative_regulation (inhibit) of Localization (sensitization) of TRPV1 in sensory neurons associated with agonist
1) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 0.14 Pain Relevance 0.39

General Comments

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