INT350430

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1)
intracellular (HSP90AA1) response to stress (HSP90AA1) cytoplasm (HSP90AA1)
Anatomy Link Frequency
colon 4
HSP90AA1 (Homo sapiens)
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 158 99.84 Very High Very High Very High
Colon Cancer 102 98.84 Very High Very High Very High
Metastasis 28 72.72 Quite High
Pressure And Volume Under Development 4 69.64 Quite High
Carcinoma 10 64.76 Quite High
Shock 16 50.00 Quite Low
Malignant Neoplastic Disease 8 48.48 Quite Low
Apoptosis 12 39.68 Quite Low
Breast Cancer 6 22.08 Low Low
Stress 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our recent observation that Hsp90 inhibition induces ATF3 in cancer cells and the lack of clarity regarding the biological effect of this transcription factor in oncology pressed our aim to define the role of ATF3 in colon cancer.
Negative_regulation (inhibition) of Hsp90 in colon Positive_regulation (induces) of ATF3 associated with cancer and colon cancer
1) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.55 Pain Relevance 0
We now have confirmed that blocking Hsp90 does indeed induce ATF3 in various cancer derived cell lines, including colon (HT29, HCT116), gastric (TMK1), and pancreatic (L3.6pl) cancer derived cells.
Negative_regulation (blocking) of Hsp90 in colon Positive_regulation (induce) of ATF3 associated with cancer
2) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.56 Pain Relevance 0

General Comments

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