INT350432

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1)
intracellular (HSP90AA1) response to stress (HSP90AA1) cytoplasm (HSP90AA1)
Anatomy Link Frequency
SW620 2
HSP90AA1 (Homo sapiens)
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 158 99.74 Very High Very High Very High
Colon Cancer 102 85.32 High High
Shock 16 50.00 Quite Low
Pressure And Volume Under Development 4 20.80 Low Low
Stress 10 15.36 Low Low
Carcinoma 10 11.08 Low Low
Metastasis 28 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 8 5.00 Very Low Very Low Very Low
Hypoxia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed we found that blocking Hsp90 induces ATF3 protein expression in human gastric (TMK-1), colon (HT29, HCT116, SW620), and pancreatic (L3.6pl) cancer cell lines (Figure 1A and [8]).
Hsp90 Positive_regulation (induces) of Gene_expression (expression) of ATF3 in SW620 associated with cancer
1) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.64 Pain Relevance 0
These results were validated in vivo using a model of subcutaneously implanted gastric (TMK-1), or pancreatic (L3.6pl) cancer cells where Hsp90 inhibitor treatment markedly induced ATF3 expression in respective tumors (Figure 1B).
Hsp90 Positive_regulation (induced) of Gene_expression (expression) of ATF3 associated with cancer
2) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.63 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox