INT350433

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KRAS, BRAF) cytosol (BRAF) signal transduction (KRAS)
mitochondrion (KRAS) nucleus (BRAF) GTPase activity (KRAS)
Anatomy Link Frequency
colon 2
KRAS (Homo sapiens)
BRAF (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 51 100.00 Very High Very High Very High
Apoptosis 6 97.64 Very High Very High Very High
Cancer 79 95.64 Very High Very High Very High
Metastasis 14 89.16 High High
Breast Cancer 3 74.48 Quite High
Malignant Neoplastic Disease 4 68.56 Quite High
Shock 8 50.00 Quite Low
Cervical Cancer 1 18.16 Low Low
Stress 5 5.00 Very Low Very Low Very Low
Carcinoma 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent publications have shown that the KRAS and BRAF mutation status of colon cancer cells influence the expression rates of multiple proliferative as well as apoptotic signaling intermediates (Kikuchi et al, Cancer Res 2009, Oliveira et al, Oncogene 2003, Seruca et al, 2009), including HIF1?
KRAS Regulation (influence) of Gene_expression (status) of BRAF in colon associated with cancer, colon cancer and apoptosis
1) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.77 Pain Relevance 0

General Comments

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