INT350434

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.44
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1)
intracellular (HSP90AA1) response to stress (HSP90AA1) cytoplasm (HSP90AA1)
Anatomy Link Frequency
colon 3
HSP90AA1 (Homo sapiens)
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 85.52 High High
cINOD 4 31.40 Quite Low
COX-2 inhibitor 4 25.12 Quite Low
Disease Link Frequency Relevance Heat
Cancer 158 100.00 Very High Very High Very High
Colon Cancer 102 98.20 Very High Very High Very High
Metastasis 28 95.04 Very High Very High Very High
Stress 10 91.96 High High
Hypoxia 6 89.32 High High
Shock 16 87.52 High High
Solid Tumor 2 84.80 Quite High
Carcinoma 10 56.16 Quite High
Pancreatic Cancer 4 36.80 Quite Low
INFLAMMATION 4 31.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, and of high clinical relevance, we could show in the current and in one preliminary previous study that ATF3 expression can be induced in cancer cells by Hsp90 inhibition in vitro and in vivo.
Negative_regulation (inhibition) of Hsp90 Positive_regulation (induced) of Gene_expression (expression) of ATF3 associated with cancer
1) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.21 Pain Relevance 0
Here we followed-up on our previous observation that inhibition of Hsp90 may increase ATF3 expression and sought to determine the role of ATF3 in colon cancer.


Negative_regulation (inhibition) of Hsp90 in colon Spec (may) Positive_regulation (increase) of Gene_expression (expression) of ATF3 in colon associated with colon cancer
2) Confidence 0.32 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC3003660 Disease Relevance 1.23 Pain Relevance 0.04

General Comments

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