INT350445

Context Info Confidence 0.30 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 3.25 Pain Relevance 0

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1) response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)

Anatomy Link Frequency colon 4 HSP90AA1 (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 4 5.00 cINOD 4 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Cancer 158 99.64 Colon Cancer 102 99.46 Metastasis 28 93.32 Malignant Neoplastic Disease 8 92.08 Apoptosis 12 83.28 Pressure And Volume Under Development 4 69.64 Breast Cancer 6 65.68 Carcinoma 10 64.76 Shock 16 50.00 Stress 10 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our recent observation that Hsp90 inhibition induces ATF3 in cancer cells and the lack of clarity regarding the biological effect of this transcription factor in oncology pressed our aim to define the role of ATF3 in colon cancer.

Positive_regulation (induces) of Negative_regulation (inhibition) of Hsp90 in colon associated with cancer and colon cancer

1) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.55 Pain Relevance 0

Hence, results from this study suggest that ATF3 functions as a tumor suppressor and anti-metastatic factor in HCT116 colon cancer, which is therapeutically inducible by blocking Hsp90.

Positive_regulation (inducible) of Negative_regulation (blocking) of Hsp90 in colon associated with cancer and colon cancer

2) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.71 Pain Relevance 0

General Comments

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