INT350445

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1)
response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)
Anatomy Link Frequency
colon 4
HSP90AA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 158 99.64 Very High Very High Very High
Colon Cancer 102 99.46 Very High Very High Very High
Metastasis 28 93.32 High High
Malignant Neoplastic Disease 8 92.08 High High
Apoptosis 12 83.28 Quite High
Pressure And Volume Under Development 4 69.64 Quite High
Breast Cancer 6 65.68 Quite High
Carcinoma 10 64.76 Quite High
Shock 16 50.00 Quite Low
Stress 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our recent observation that Hsp90 inhibition induces ATF3 in cancer cells and the lack of clarity regarding the biological effect of this transcription factor in oncology pressed our aim to define the role of ATF3 in colon cancer.
Positive_regulation (induces) of Negative_regulation (inhibition) of Hsp90 in colon associated with cancer and colon cancer
1) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.55 Pain Relevance 0
Hence, results from this study suggest that ATF3 functions as a tumor suppressor and anti-metastatic factor in HCT116 colon cancer, which is therapeutically inducible by blocking Hsp90.
Positive_regulation (inducible) of Negative_regulation (blocking) of Hsp90 in colon associated with cancer and colon cancer
2) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.71 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox