INT350477

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tlr4, Irf3) signal transduction (Tlr4) nucleus (Irf3)
plasma membrane (Tlr4) intracellular (Tlr4) DNA binding (Irf3)
Tlr4 (Mus musculus)
Irf3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 61.68 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 27 69.36 Quite High
Shock 2 43.28 Quite Low
Coronary Artery Disease 4 27.04 Quite Low
Reperfusion Injury 4 25.36 Quite Low
Injury 11 5.00 Very Low Very Low Very Low
Hypertrophy 10 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 9 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR4 can activate TRIF-dependent pathways without MyD88 association, leading to activation of the transcription factor IRF3, in turn producing interferon and costimulatory molecules.


TLR4 Positive_regulation (activate) of Positive_regulation (activation) of IRF3
1) Confidence 0.22 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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