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Context Info
Confidence 0.68
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.12
Pain Relevance 0.66

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signal transduction (TNFSF14) extracellular space (TNFSF14) extracellular region (TNFSF14)
plasma membrane (TNFSF14) cytoplasm (TNFSF14)
TNFSF14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lamotrigine 32 100.00 Very High Very High Very High
carbamazepine 22 100.00 Very High Very High Very High
pregabalin 1 88.24 High High
anticonvulsant 8 86.28 High High
chemokine 1 84.84 Quite High
Pain 1 78.96 Quite High
abdominal pain 1 68.00 Quite High
headache 3 67.36 Quite High
iatrogenic 1 61.84 Quite High
cINOD 2 55.28 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 125 99.64 Very High Very High Very High
Nephrotoxicity 5 97.96 Very High Very High Very High
Epilepsy 73 97.16 Very High Very High Very High
Toxicity 6 96.16 Very High Very High Very High
Alzheimer's Dementia 5 94.68 High High
Renal Failure 4 93.60 High High
Cognitive Disorder 1 93.44 High High
Overweight 1 90.60 High High
Volume Depletion And Dehydration 1 89.96 High High
Amyloid Plaque 1 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another non-congophilic substance was revealed using the Avidin-Biotin peroxidase complex to localize lambda light chains by light microscopy and corresponded to a granular substance in electron microscopy.
Localization (localize) of light
1) Confidence 0.68 Published 1987 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 3110902 Disease Relevance 0.91 Pain Relevance 0.08
Excluding dysglobulinemias with urinary excretion of immunoglobulin light chains, which represent a special case of maximum nephrotoxicity, 4 main risk factors of renal toxicity have been identified in nondiabetic subjects: previous renal failure with serum creatinine levels greater than 140 mumol per liter, extracellular dehydration, age over 60 and use of high doses of ICA and/or repeated ICA injections before serum creatinine levels return to baseline.
Localization (excretion) of light associated with nephrotoxicity, toxicity, renal failure and volume depletion and dehydration
2) Confidence 0.68 Published 1994 Journal Ann Radiol (Paris) Section Abstract Doc Link 8085753 Disease Relevance 1.07 Pain Relevance 0.09
AEDs that can be taken once daily (eg, PHT, ZNS, TPM, and extended-release forms of CBZ, LTG, and LEV) have a clear advantage in patients for whom denial of their epilepsy can frequently lead to poor compliance.
Localization (release) of LTG associated with epilepsy, lamotrigine and carbamazepine
3) Confidence 0.28 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2898168 Disease Relevance 0.58 Pain Relevance 0.19
These findings indicate that the inhibitory effects of evodiamine and rutaecarpine on LIGHT-induced migration and the activation of CCR1, CCR2, ICAM-1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
Localization (migration) of LIGHT
4) Confidence 0.09 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.26 Pain Relevance 0.18
As for LTG, evidence for association with treatment response has thus far been reported for DRD2, ?
Localization (reported) of LTG associated with lamotrigine
5) Confidence 0.07 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.29 Pain Relevance 0.13

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