INT3505

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Context Info
Confidence 0.39
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.60
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
Anatomy Link Frequency
joint 1
platelets 1
midbrain 1
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 100.00 Very High Very High Very High
Dopamine 88 99.80 Very High Very High Very High
substance P 10 99.72 Very High Very High Very High
carbamazepine 6 98.72 Very High Very High Very High
local anesthetic 4 97.88 Very High Very High Very High
Spinal cord 2 97.78 Very High Very High Very High
midbrain 2 97.36 Very High Very High Very High
tolerance 6 97.14 Very High Very High Very High
Pain 6 96.84 Very High Very High Very High
Arthritis 81 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 25 100.00 Very High Very High Very High
Nociception 4 98.88 Very High Very High Very High
Disease 51 97.40 Very High Very High Very High
Diabetes Mellitus 45 96.96 Very High Very High Very High
Pain 6 96.84 Very High Very High Very High
Rheumatoid Arthritis 77 95.76 Very High Very High Very High
Restless Legs Syndrome 168 94.16 High High
Thyroid Disease 14 90.36 High High
Synovitis 12 83.24 Quite High
Hypothyroidism 8 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such platelets did not aggregate with COLL or TH, but did aggregate with A23187-an effect blocked by local anesthetics.
TH Binding (aggregate) of in platelets associated with local anesthetic
1) Confidence 0.39 Published 1976 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 772186 Disease Relevance 0 Pain Relevance 0.40
No significant changes were seen with the SP antibody but immunolabeling for nNOS, H02 (Figure 2) and TH (Figure 1) was decreased (by 40–50%) in the patient with poorly controlled diabetes.



TH Binding (immunolabeling) of associated with diabetes mellitus and substance p
2) Confidence 0.26 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.29 Pain Relevance 0.22
In addition, subclinical hyperthyroidism is also more common (2%) in elderly subjects.50

“Growing pains” are common in childhood RLS,51 and some adult patients also complain of pain concomitant with other classical symptoms of RLS in the legs.3,5 A very important study by Ondo and colleagues (2000) demonstrated that the dopaminergic system in rats sends long projections from the midbrain into the spinal cord, which influences the gating of peripheral nociceptive input.52 With the profuse data demonstrating the tight interactions between TH and DA, it seems plausible that TH mediates these nociceptive inputs and that pain ensues when these inputs are not counterbalanced by DA.

TH Binding (interactions) of in midbrain associated with nociception, pain, dopamine, thyroid disease, midbrain, restless legs syndrome and spinal cord
3) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.00 Pain Relevance 0.51
This drug, an inducer and substrate of CYP450, slowly causes tolerance because the induction of CYP also increases the speed with which carbamazepine itself is metabolized, rendering it less effective at inducing metabolism of TH.
TH Binding (metabolism) of associated with tolerance and carbamazepine
4) Confidence 0.03 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.68 Pain Relevance 0.38
Our data provide an immunologic explanation for this clinical observation by demonstrating that the presence of the pro-inflammatory and osteoclastogenic Th17 cell subset in the inflamed joint strongly correlates with both disease activity and local PDUS score in RA.
Th17 Binding (presence) of in joint associated with inflammation, disease and arthritis
5) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.63 Pain Relevance 0.30

General Comments

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