INT350518

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1) response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)

HSP90AA1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 5.00 palliative 1 5.00 chemokine 1 5.00 Nicotine 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Epilepsy 1 95.60 Apoptosis 21 90.80 Myeloid Leukemia 25 89.76 Leukemia 3 36.16 Myeloproliferative Disorder 45 5.00 Myelodysplastic Syndromes 38 5.00 Myelofibrosis 30 5.00 Cancer 9 5.00 Chronic Neutrophilic Leukemia 7 5.00 Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, Okabe et al., demonstrated that FK228 treatment induces a diverse range of histone and non-histone protein acetylation in BCR-ABL transfected cell lines, including acetylation of p53, Hsp90 and BCR-ABL [81].

Phosphorylation (acetylation) of Hsp90

1) Confidence 0.16 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.72 Pain Relevance 0

General Comments

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