INT350519

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (STK19) kinase activity (STK19)
STK19 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 25 98.32 Very High Very High Very High
Cancer 9 86.96 High High
Apoptosis 21 83.56 Quite High
Blast Crisis 1 54.80 Quite High
Philadelphia Chromosome 1 37.72 Quite Low
Myeloproliferative Disorder 45 30.08 Quite Low
Chronic Myeloid Leukemia 4 29.48 Quite Low
Myelodysplastic Syndromes 38 5.00 Very Low Very Low Very Low
Myelofibrosis 30 5.00 Very Low Very Low Very Low
Chronic Neutrophilic Leukemia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, analyses of the expression and functional activity of HDACs and HATs in the imatinib resistant CML cell line K562 have indicated that Class I (HDAC1, 2 and 3), Class IIA (HDAC4) and Class III (SIRT1) HDACs are all elevated and increased compared to imatinib sensitive cells, whereas the levels of HATs are decreased [12, 74].
Positive_regulation (elevated) of Class III associated with myeloid leukemia
1) Confidence 0.01 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.59 Pain Relevance 0

General Comments

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