INT35058

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1987
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 7.21
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLAUR) extracellular region (PLAUR) plasma membrane (PLAUR)
enzyme binding (PLAUR)
Anatomy Link Frequency
SK-MEL-28 1
monocyte 1
External 1
pre-B lymphocytes 1
PLAUR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 30 99.88 Very High Very High Very High
Chronic pancreatitis 2 99.84 Very High Very High Very High
Angina 4 89.04 High High
aspirin 2 83.16 Quite High
Inflammation 7 80.40 Quite High
cva 1 59.68 Quite High
palliative 2 55.12 Quite High
anesthesia 2 53.72 Quite High
imagery 1 52.40 Quite High
COX-2 inhibitor 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1 100.00 Very High Very High Very High
Myocardial Infarction 24 99.84 Very High Very High Very High
Adenoma 5 99.84 Very High Very High Very High
Pancreatitis 2 99.84 Very High Very High Very High
Adhesions 24 98.62 Very High Very High Very High
Carcinoma 5 98.52 Very High Very High Very High
Colorectal Cancer 11 97.20 Very High Very High Very High
Coronary Stenosis 1 96.44 Very High Very High Very High
Thrombosis Related Under Development 2 95.32 Very High Very High Very High
Cancer 83 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, possible up-regulation of uPAR in acute myocardial infarction (AMI) may affect monocyte adhesion.
Spec (possible) Positive_regulation (up-regulation) of uPAR in monocyte associated with adhesions and myocardial infarction
1) Confidence 0.61 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 0.77 Pain Relevance 0.08
Mouse pre-B lymphocytes (BAF3 cells) transfected with various amounts of uPAR complementary DNA showed a strong correlation of uPAR expression with beta(2)-integrin-dependent adhesion to intercellular adhesion molecule 1, thus providing evidence for the functional relevance of uPAR up-regulation in an isolated in vitro system.
Positive_regulation (up-regulation) of uPAR in pre-B lymphocytes associated with adhesions
2) Confidence 0.61 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.23 Pain Relevance 0.04
Compared with control mucosa urokinase activity was significantly elevated in adenomas (P less than 0.001) and carcinomas, levels being significantly higher in carcinomas (P less than 0.05).
Positive_regulation (elevated) of urokinase associated with adenoma and carcinoma
3) Confidence 0.57 Published 1987 Journal Br J Surg Section Abstract Doc Link 3111578 Disease Relevance 0.93 Pain Relevance 0.06
The expression level of uPAR mRNA increased in a dose-dependent manner on IL-1beta stimulation.
Positive_regulation (increased) of uPAR mRNA
4) Confidence 0.45 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.46 Pain Relevance 0.07
Hierarchical clustering using only the 106 transcripts identified by class comparison revealed two main expression motifs in the melanoma cell lines (Figure 1A): Motif 1 distinguished eight cell lines (NZM09, NZM11, NZM19, NZM22, NZM40, NZM52, SK-MEL-28, UACC62), and consisted of down-regulation of genes involved in neural crest and melanocyte development, differentiation, and pigmentation (e.g., EDNRB, MITF, MLANA, TYR; Table S1), and up-regulation of genes related to angiogenesis, neurogenesis, immunomodulation, and interaction and remodelling of the extracellular environment (e.g., HIF1a, NRP1, PLAUR, TGFBI; Table S1); Motif 2 distinguished the remaining 19 cell lines, and showed a pattern of gene expression that tended to be the inverse of Motif 1, with down-regulation of extracellular remodelling genes and up-regulation of MITF and melanocyte lineage markers, although not all Motif 2 cell lines had higher levels of MITF expression (e.g.
Positive_regulation (up-regulation) of PLAUR in SK-MEL-28 associated with melanoma and neurodegenerative disease
5) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.33 Pain Relevance 0
The median effective dosage requirement of urokinase to reperfuse 50% of the treated patients was 180,000 IU.
Positive_regulation (requirement) of urokinase
6) Confidence 0.27 Published 1987 Journal Clin Cardiol Section Abstract Doc Link 3581531 Disease Relevance 0.33 Pain Relevance 0.12
Enhanced urokinase plasminogen activation in chronic pancreatitis suggests a role in its pathogenesis.
Positive_regulation (activation) of urokinase associated with chronic pancreatitis
7) Confidence 0.09 Published 1997 Journal Gastroenterology Section Title Doc Link 9287983 Disease Relevance 0.10 Pain Relevance 0.19
NSAIDs also stimulate peroxisome proliferator activator-receptor (PPAR)-?
Positive_regulation (stimulate) of activator-receptor associated with cinod
8) Confidence 0.02 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.22 Pain Relevance 0.75
NSAIDs also stimulate peroxisome proliferator activator-receptor (PPAR)-?
Positive_regulation (stimulate) of activator-receptor associated with cinod
9) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 0.94 Pain Relevance 0.80
Currently available fibrin-unspecific plasminogen activators such as streptokinase and urokinase are effective thrombolytic agents but do not fulfill all the criteria of an ideal plasminogen activator.
Positive_regulation (activators) of urokinase
10) Confidence 0.01 Published 1988 Journal Klin. Wochenschr. Section Abstract Doc Link 3279257 Disease Relevance 0.40 Pain Relevance 0
The hypothesis of this study was that EPC devices increase the level of urokinase plasminogen activator (uPA), a second activator of fibrinolysis.
Positive_regulation (increase) of urokinase
11) Confidence 0.00 Published 2002 Journal J. Vasc. Surg. Section Abstract Doc Link 12422101 Disease Relevance 0.25 Pain Relevance 0
External pneumatic compression does not increase urokinase plasminogen activator after abdominal surgery.
Neg (not) Positive_regulation (increase) of urokinase in External
12) Confidence 0.00 Published 2002 Journal J. Vasc. Surg. Section Title Doc Link 12422101 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox