INT350588

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Context Info
Confidence 0.38
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (Mlh1) ATPase activity (Mlh1) nucleus (Mlh1)
cell cycle (Mlh1)
Anatomy Link Frequency
MLH1 3
Mlh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 54 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 42 99.48 Very High Very High Very High
Cancer 189 98.72 Very High Very High Very High
Chromosomal Instability 3 89.04 High High
Genomic Instability 21 87.00 High High
Lung Cancer 27 77.28 Quite High
Toxicity 33 63.28 Quite High
Death 12 51.52 Quite High
Intestinal Cancer 108 49.76 Quite Low
Hyperplasia 51 15.32 Low Low
Stress 63 13.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSI is often a result of the loss or hindrance of DNA mismatch repair (MMR) genes such as MutL homolog 1 (MLH1).
Negative_regulation (loss) of MLH1 in MLH1 associated with microsatellite instability
1) Confidence 0.38 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 1.12 Pain Relevance 0
Immunoprecipitation of methylated H3K9 following Cr(VI) exposure was shown to coprecipitate the MLH1 promoter; moreover, the treatment of cells with Cr(VI) produced time- and dose-dependent decreases in messenger RNA (mRNA) levels of MLH1 (Sun et al., 2009).
Negative_regulation (decreases) of MLH1 in MLH1
2) Confidence 0.38 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 0.80 Pain Relevance 0
MSI is often a result of the loss or hindrance of DNA mismatch repair (MMR) genes such as MutL homolog 1 (MLH1).
Negative_regulation (loss) of MutL homolog 1 in MLH1 associated with microsatellite instability
3) Confidence 0.38 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 1.12 Pain Relevance 0

General Comments

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