INT3506

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Context Info
Confidence 0.81
First Reported 1976
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 12
Total Number 18
Disease Relevance 0.78
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
Anatomy Link Frequency
mesencephalon 4
neurons 3
cortex 2
visceral 1
smooth muscle 1
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 32 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
substance P 15 99.92 Very High Very High Very High
Neuropeptide 10 99.84 Very High Very High Very High
Substantia nigra 131 99.56 Very High Very High Very High
midbrain 55 98.74 Very High Very High Very High
Dopamine 107 98.60 Very High Very High Very High
Neurotransmitter 6 98.02 Very High Very High Very High
adenocard 1 97.28 Very High Very High Very High
Anterior cingulate cortex 4 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 4 99.44 Very High Very High Very High
Toxicity 28 85.32 High High
Disease 75 84.48 Quite High
Urological Neuroanatomy 6 58.92 Quite High
Opiate Addiction 27 46.80 Quite Low
Newborn Drug Withdrawal Syndrome 37 35.68 Quite Low
Parkinson's Disease 54 27.92 Quite Low
Increased Venous Pressure Under Development 4 25.00 Low Low
Pain 12 5.00 Very Low Very Low Very Low
Poisoning 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunocytochemical localization of tyrosine hydroxylase (TH) and methionine-enkephalin (met-enkephalin) was determined at two representative caudal and rostral levels of the human mesencephalon.
Spec (determined) Localization (localization) of TH in mesencephalon associated with enkephalin
1) Confidence 0.81 Published 1983 Journal J. Neurol. Sci. Section Abstract Doc Link 6131945 Disease Relevance 0 Pain Relevance 0.38
The immunocytochemical localization of tyrosine hydroxylase (TH) and methionine-enkephalin (met-enkephalin) was determined at two representative caudal and rostral levels of the human mesencephalon.
Spec (determined) Localization (localization) of tyrosine hydroxylase in mesencephalon associated with enkephalin
2) Confidence 0.81 Published 1983 Journal J. Neurol. Sci. Section Abstract Doc Link 6131945 Disease Relevance 0 Pain Relevance 0.38
Immunohistochemical localization of serotonin, leu-enkephalin, tyrosine hydroxylase, and substance P within the visceral sensory area of cartilaginous fish.
Localization (localization) of tyrosine hydroxylase in visceral associated with enkephalin, serotonin and substance p
3) Confidence 0.78 Published 1992 Journal Cell Tissue Res. Section Title Doc Link 1377604 Disease Relevance 0 Pain Relevance 0.79
Immunohistochemical localization of tyrosine hydroxylase, substance P, neuropeptide-Y and leucine-enkephalin in developing human retinal amacrine cells.
Localization (localization) of tyrosine hydroxylase in amacrine cells associated with neuropeptide, enkephalin and substance p
4) Confidence 0.77 Published 1994 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 7513625 Disease Relevance 0 Pain Relevance 0.64
Tyrosine hydroxylase was localized between 10 and 12 weeks of gestation, substance P and neuropeptide Y appeared little later around 14 weeks, and leucine-enkephalin-like immunoreactivity was observed at 16 weeks.
Localization (localized) of Tyrosine hydroxylase associated with neuropeptide, enkephalin and substance p
5) Confidence 0.77 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7513625 Disease Relevance 0 Pain Relevance 0.63
The immunocytochemical localization of tyrosine hydroxylase (TH) and methionine-enkephalin (met-enkephalin) was determined at two representative caudal and rostral levels of the human mesencephalon.
Spec (determined) Localization (localization) of tyrosine hydroxylase in mesencephalon associated with enkephalin
6) Confidence 0.71 Published 1983 Journal J. Neurol. Sci. Section Abstract Doc Link 6131945 Disease Relevance 0 Pain Relevance 0.38
The immunocytochemical localization of tyrosine hydroxylase (TH) and methionine-enkephalin (met-enkephalin) was determined at two representative caudal and rostral levels of the human mesencephalon.
Spec (determined) Localization (localization) of TH in mesencephalon associated with enkephalin
7) Confidence 0.71 Published 1983 Journal J. Neurol. Sci. Section Abstract Doc Link 6131945 Disease Relevance 0 Pain Relevance 0.38
The lack of NT-TH colocalization in human, contrasts with previous findings in the rodent cortex, where a contingent of the DA cortical afferents contains NT.
Localization (colocalization) of NT-TH in cortex
8) Confidence 0.70 Published 1990 Journal Brain Res. Section Abstract Doc Link 2265353 Disease Relevance 0.06 Pain Relevance 0.23
Secretion due to COLL, but not to TH, required extracellular Ca++ and was accompanied by increased uptake of 45Ca which was inhibited by local anesthetics.
Localization (Secretion) of TH associated with local anesthetic
9) Confidence 0.69 Published 1976 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 772186 Disease Relevance 0 Pain Relevance 0.27
Neuropeptide Y- and tyrosine hydroxylase-positive nerve fibers were most abundant and localized mainly in the smooth muscle layer.
Localization (localized) of tyrosine hydroxylase in smooth muscle associated with neuropeptide
10) Confidence 0.68 Published 1995 Journal Acta Histochem. Section Abstract Doc Link 7771181 Disease Relevance 0 Pain Relevance 0.23
The lack of NT-TH colocalization in human, contrasts with previous findings in the rodent cortex, where a contingent of the DA cortical afferents contains NT.
Localization (colocalization) of NT-TH in cortex
11) Confidence 0.65 Published 1990 Journal Brain Res. Section Abstract Doc Link 2265353 Disease Relevance 0.06 Pain Relevance 0.23
The production and secretion of multiple peptide hormones and tyrosine hydroxylase by the human neuroblastoma cell line NB-1 and the effects of dibutyryl cAMP (Bt2cAMP) and phorbol esters such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on them were investigated.
Spec (investigated) Localization (secretion) of tyrosine hydroxylase associated with neuroblastoma
12) Confidence 0.48 Published 1992 Journal Virchows Arch., B, Cell Pathol. Section Abstract Doc Link 1279891 Disease Relevance 0.17 Pain Relevance 0.11
The results indicated that treatment with Bt2cAMP and TPA induces the expression of multiple genes of peptide hormone and tyrosine hydroxylase and increases hormone production and secretion through morphological changes into endocrine cells.
Localization (secretion) of tyrosine hydroxylase in endocrine cells
13) Confidence 0.48 Published 1992 Journal Virchows Arch., B, Cell Pathol. Section Abstract Doc Link 1279891 Disease Relevance 0.14 Pain Relevance 0.25
In contrast, after differentiation, strong TH expression was shown in the ReNcell VM neurons both by Western blot and immunocytochemical analysis (colabelling of TH and ?
Localization (colabelling) of TH in neurons associated with midbrain
14) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1888696 Disease Relevance 0 Pain Relevance 0.19
Expression of GFP following delivery of AAV1/2-GFP to the SN was also shown to co-localize with TH-immunoreactive neurons (confirmed with z-stacks) throughout the SN (Figure 1C, D).
Localization (localize) of TH-immunoreactive in neurons associated with substantia nigra
15) Confidence 0.40 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.15 Pain Relevance 0.36
Co-localization of TH and ?
Localization (localization) of TH
16) Confidence 0.35 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.20 Pain Relevance 0.35
This was confirmed by the fluorescent double labeling against TH and AADC showing that AADC-positive neurons were not colocalized with TH-positive neurons within the A11 group (Fig. 7F–K).
Neg (not) Localization (colocalized) of TH-positive in neurons
17) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.22
In particular, there are consistent decreases in protein, DNA, RNA and neurotransmitter content (serotonin, dopamine, norepinephrine) [87, 145, 253, 301, 344], enzymatic protein levels (tyrosine hydroxylase, acetylcholine-esterase, choline acetyltransferase, ornithine decarboxylase) [87, 224, 327, 338, 342, 343], and receptor expression (?
Localization (choline acetyltransferase) of tyrosine hydroxylase associated with dopamine, neurotransmitter and serotonin
18) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0 Pain Relevance 0.65

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