INT350632

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 6.22
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17f) extracellular region (Il17f)
Anatomy Link Frequency
Th17 cells 1
Il17f (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 144 99.24 Very High Very High Very High
Multiple sclerosis 158 97.24 Very High Very High Very High
cytokine 120 92.96 High High
Spinal cord 2 77.24 Quite High
Inflammation 91 68.00 Quite High
Inflammatory mediators 7 55.36 Quite High
Central nervous system 27 21.04 Low Low
chemokine 9 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 227 99.24 Very High Very High Very High
Inflammatory Bowel Disease 163 97.68 Very High Very High Very High
Demyelinating Disease 175 97.24 Very High Very High Very High
Autoimmune Disease 46 96.16 Very High Very High Very High
Multiple Sclerosis 20 86.72 High High
INFLAMMATION 95 68.00 Quite High
Congenital Anomalies 3 51.04 Quite High
Central Nervous System Disease 27 21.04 Low Low
Adhesions 2 15.24 Low Low
Ileal Diseases 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In ileal CD samples, IL22 (P = 0.0015) was strongly induced, while IL17A (P = 0.013), IL26 (P = 0.029) and IL17F (P = 0.019) were weakly induced, and expression levels of IL21 were similar to those in ileal controls.
Positive_regulation (induced) of IL17F associated with crohn's disease
1) Confidence 0.29 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.78 Pain Relevance 0.55
In UC samples, IL17A (P = 0.0002), IL21 (P = 0.0021), IL22 (P = 0.0003) and IL26 (P = 0.0017) were strongly induced, and IL17F (P = 0.046) was weakly induced, while in colonic CD samples, IL17A (P = 0.0084) and IL22 (P = 0.001) were strongly induced, and IL21 (P = 0.047), IL26 (P = 0.048) and IL17F (P = 0.011) were weakly induced (Figure 2B).
Positive_regulation (induced) of IL17F associated with inflammatory bowel disease and crohn's disease
2) Confidence 0.29 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.46 Pain Relevance 0.48
In UC samples, IL17A (P = 0.0002), IL21 (P = 0.0021), IL22 (P = 0.0003) and IL26 (P = 0.0017) were strongly induced, and IL17F (P = 0.046) was weakly induced, while in colonic CD samples, IL17A (P = 0.0084) and IL22 (P = 0.001) were strongly induced, and IL21 (P = 0.047), IL26 (P = 0.048) and IL17F (P = 0.011) were weakly induced (Figure 2B).
Positive_regulation (induced) of IL17F associated with inflammatory bowel disease and crohn's disease
3) Confidence 0.29 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.51 Pain Relevance 0.52
Th17 cells produce IL-17A and IL-17F, which are upregulated in chronic lesions [172, 173], and IL-22 which is also involved in MS pathogenesis.
Positive_regulation (upregulated) of IL-17F in Th17 cells associated with multiple sclerosis
4) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.47 Pain Relevance 0.41

General Comments

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