INT350691

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Context Info
Confidence 0.08
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DICER1) intracellular (DICER1) helicase activity (DICER1)
cytoplasm (DICER1)
Anatomy Link Frequency
thymocytes 1
T cell 1
DICER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 56 92.52 High High
cytokine 54 91.52 High High
tolerance 10 79.20 Quite High
Multiple sclerosis 316 5.00 Very Low Very Low Very Low
Central nervous system 54 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 14 99.68 Very High Very High Very High
Autoimmune Disease 92 96.92 Very High Very High Very High
INFLAMMATION 70 92.52 High High
Disease 136 92.00 High High
Lymphoproliferative Disease 8 78.64 Quite High
Targeted Disruption 14 71.12 Quite High
Syndrome 10 69.88 Quite High
Systemic Lupus Erythematosus 6 68.88 Quite High
Death 14 66.32 Quite High
Cancer 16 61.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific deletion of either Drosha or Dicer phenocopies mice lacking a functional Treg cell-specific transcription factor Foxp3 gene or Foxp3(+) cells whereas deletion throughout the T cell compartment also results in spontaneous inflammatory disease, but later in life [112].
Localization (deletion) of Dicer in T cell associated with inflammation and disease
1) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.79 Pain Relevance 0.13
Deletion of Dicer at an early stage of T cell development compromised the survival of alpha-beta lineage cells whereas the numbers of gamma-delta-expressing thymocytes were not affected in developing thymocytes [101].
Localization (Deletion) of Dicer in thymocytes
2) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.38 Pain Relevance 0.10

General Comments

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