INT350692

Context Info Confidence 0.02 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0.08

DNA binding (Bcl6, Hand1) nucleus (Bcl6, Hand1) cell differentiation (Hand1) nucleoplasm (Hand1) cell morphogenesis (Bcl6) intracellular (Bcl6)

Anatomy Link Frequency Th17 cell 1 Bcl6 (Mus musculus) Hand1 (Mus musculus)

Pain Link Frequency Relevance Heat addiction 1 94.56 cytokine 27 72.72 tolerance 5 23.40 Multiple sclerosis 158 5.00 Inflammation 28 5.00 Central nervous system 27 5.00 Inflammatory response 4 5.00 Demyelination 4 5.00 chemokine 3 5.00 Spinal cord 2 5.00

Disease Link Frequency Relevance Heat Demyelinating Disease 175 90.60 Repression 9 72.56 Autoimmune Disease 46 49.44 Cancer 8 15.96 Death 7 13.72 Lymphoproliferative Disease 4 8.44 Disease 68 5.00 INFLAMMATION 35 5.00 Central Nervous System Disease 27 5.00 Multiple Sclerosis 20 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Bcl-6, a transcriptional repressor, binds to the promoters of the Th1 and Th17 cell transcriptional regulators T-bet and RORgammat and represses IFN-?

Bcl-6 Binding (binds) of Th1 in Th17 cell

1) Confidence 0.02 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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