INT350699

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Context Info
Confidence 0.04
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.81
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Casp8, Stat3) nucleus (Casp8, Stat3) mitochondrion (Casp8)
DNA binding (Stat3) protein complex (Casp8) signal transducer activity (Stat3)
Casp8 (Mus musculus)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 158 98.98 Very High Very High Very High
Central nervous system 27 84.48 Quite High
Inflammation 28 77.40 Quite High
cytokine 27 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 175 98.98 Very High Very High Very High
Disease Susceptibility 2 91.04 High High
Central Nervous System Disease 27 84.48 Quite High
Infection 6 77.68 Quite High
INFLAMMATION 35 77.40 Quite High
Disease 68 67.84 Quite High
Recurrence 7 60.56 Quite High
Autoimmune Disease 46 46.44 Quite Low
Epstein-barr Virus 1 38.48 Quite Low
Experimental Autoimmune Encephalomyelitis 1 13.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The major genetic factor in MS is the major histocompatibility complex [159], however recent genomewide association studies revealed new susceptibility alleles for MS that are all related with immune functions (e.g., CASP8, CD58, STAT3, interleukin 7 receptor (IL7RA; CD127), interleukin 2 receptor A (IL2RA)) [20, 160, 161].
CASP8 Binding (interleukin 7 receptor) of STAT3 associated with multiple sclerosis
1) Confidence 0.04 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.81 Pain Relevance 0.58

General Comments

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